急性缺血性卒中后胆固醇和甘油三酯水平与预后的研究

Study on the Serum Cholesterol and Triglyceride Levels and the Prognosis of the Post Acute Ischemic Stroke

目的:探讨急性缺血性卒中患者入院时胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)水平对预后的影响,了解影响急性缺血性卒中患者TC、TG水平的因素。方法:选择急性缺血性卒中患者216例。所有患者均在入院时采用美国国立卫生院卒中评分(national institute of health stroke score,NIHSS)进行临床神经功能缺损程度的评定,并在发病1、3、5个月时进行Barthel生活指数(Barthel Index,BI)评分,BI作为评价预后的主要指标。结果:①应用Logistic多元回归分析发现,影响血清TC、TG水平的因素有意识障碍、吞咽困难和入院神经功能缺损。②高TG患者组发病1、3个月时BI值明显高于正常或降低TG患者组。结论:①意识障碍、吞咽困难和入院时病情严重程度影响患者入院时血清TC、TG水平。②入院时TG水平可能与缺血性卒中患者发病1、3个月预后有关,血清TC水平和缺血性卒中患者预后可能无关。

Objective：To study serum blood cholesterol and triglyceride levels effect on the prognosis, and understand the influencing factors of blood cholesterol and triglyceride levels in the acute ischemic stroke patients. Methods： Choosing 216 patients with acute ischemic stroke. All patients were tested for clinical neurological deficits adopting the National Hospital Stroke Score （national institute of health stroke score） of the United States after admission, and evaluated according to Barthel life index （Barthel Index, BI） on the onset of on the first month, the third month, and the fifth month and give the judgment for daily life activities adopting inci-dence on the first month, the third month, and the fifth month to regard BI as the main targets of the prognosis evaluation. Results： ① Logistic multiple regression analysis found that effect with serum TC and TG level has awareness,dysphagia and obstacles to the admission neurological deficit.②patients with high triglyceride group incidence on the first month BI and the third month was significantly higher than normal or lower triglyeeride patient group. Conclusion：①Dysphagia , Sense of obstacles and admission is the severity of patients on the factors of serum TC, TG levels.②TG levels have relation with the prognosis of onset on the first month and the third month in the acute ischemic stroke patients, but TC levels have not relation with them.