上皮-钙粘素和粘着斑激酶在星形细胞瘤中的表达及意义

Expressions and significances of E-cadherin and FAK in human astrocytoma

目的探讨上皮-钙粘素(E-cadherin)和粘着斑激酶(FAK)在星形瘤中的表达及临床意义。方法采用S-P免疫组化方法检测E-cadherin、FAK在48例不同级别星形细胞瘤及12例正常脑组织中的表达。结果E-cadherin和FAK在正常脑组织与星形细胞瘤之间及星形细胞瘤高低级别组之间差异有统计学意义(P<0.05),E-cadherin的表达随着星形细胞瘤级别的升高而降低,FAK的表达随着星形细胞瘤级别的升高而升高,且二者在星形细胞瘤中的表达呈负相关(r=-0.354,P<0.01)。结论FAK的过度表达和E-cadherin的表达下调在星形细胞瘤的侵袭及恶性进展中起着重要作用,两者的表达可能与星形细胞瘤患者的预后密切相关,提示可作为反映星形细胞瘤恶性程度及预后的指标。

Objective To explore the expressions and significances of E - cadherin and FAK in human astrocytoma. Methods The expressions of E - cadherin and FAK in 48 cases of astrocytoma tissues and 12 cases of normal brain tissues were detected by immunohistochemical S - P technique. Results The positive expressions rates of E - cadherin and FAK in human astrocytoma of grades Ⅰ - Ⅱ were significantly higher than those in normal brain tissue （P 〈 0.05 ）, The positive expression rate of E - cadherin was decreased with the elevated levels of astrocytoma, and The positive expression rate of FAK was rised with the elevated levels of astrocytoma, and the expression of E - cadherin was negatively correlated with the expressions of FAK （r = - 0. 354, P 〈 0. 01 ） . Conclusion The over expressions of FAK and the low expression of E - cadherin may play an important role in the invasion and malignant progress of human astrocytoma, The expressions of E - cadherin and FAK were closely related with the prognoses of the patients with astrocytomas, and may act as valuable indicators of the malignant degree of astrocytoma and the prognosis in the patients with astrocytomas.