摘要
近年胰岛素信号障碍-胰岛素抵抗与肿瘤的密切关系日渐引起关注。胰岛素抵抗不仅可促进肿瘤的发病,而且恶化肿瘤的预后,其病理机制涉及胰岛素及胰岛素样生长因子(IGF)增多、胰岛素样生长因子结合蛋白(IGFBP-1)减少、性激素活性增加以及炎症介质刺激等因素作用。改善胰岛素信号途径的措施可降低肿瘤的发病,改善肿瘤的预后。胰岛素信号途径是否可成为肿瘤治疗的新靶点,值得关注。
The review examines evidence that aberrant insulin signalling may influence both the risk and the prognosis of cancer. Clinical and experimental evidences suggest that the higher cancer risk associated with insulin resistance may be related to aberrant insulin signalling through high levels of insulin and insulin-like growth factor type 1 （ IGF - 1 ） , low levels of insulin-like growth factor binding protein （ IGFBP） , increased activity of endogenous oestrogen and androgen, and inflammation mediators. The putative role of increased insulin sensitivity in the treatment or prevention of cancer indicates insulin signaling pathway driving cancer as a target for pharmacological intervention.
出处
《癌症进展》
2009年第1期66-72,共7页
Oncology Progress
