家族特应性聚集与儿童哮喘表型关系的研究

目的研究家族特应性聚集与儿童哮喘表型的关系。方法对2007年4月至2008年5月本院呼吸专科就诊的216例哮喘患儿进行问卷调查及临床检查，并根据有无家族特应性疾病史分为家族特应性（A组）和无家族特应性（B组）两组，比较两组哮喘患儿特应性疾病的患病率、哮喘严重程度及血清总IgE（TIgE）、户尘螨特异性IgE（DlIgE）水平。结果A组哮喘患儿特应性患病率为81．15％，与B组45．74％比较，有显著性差异（P〈0．05）；A组哮喘患儿，TIgE为（768．40±524．26）IU／mL，与B组患儿TIgE（597．16±565．38）IU／mL相比较，有显著性差异（P〈0．05）；A组哮喘患儿DlIgE为（62．35±51．14）kua／L，与B组患儿D1IgE（59．43±60．77）kua／L相比较，无显著性差异（P〉0．05）；A组哮喘患儿重度哮喘患病率为10．66％，与B组的重度哮喘患病率3．19％比较，有显著性差异（P〈0．05）；A组哮喘患儿中度哮喘患病率为30．33％，与B组的中度哮喘患病率12．77％比较，有显著性差异（P〈0．05）；两组患儿间歇发作、轻度哮喘患病率分别比较，无显著性差异（P均〉0．05）。重度哮喘患儿TIgE（1326．04±635．48）IU／mL，与非重度哮喘患儿TIgE（650．05±539．10）IU／mL相比较，差异有统计学意义（P〈0．05）。结论家族特应性聚集与患儿哮喘表型之间有一定的关系，有家族特应性聚集的哮喘息儿易患特应性疾病，病情较严重，TIgE水平更高。

Objective To investigate the relationship between familial aggregation of atopy and asthma phenotypes in children. Methods A total of 216 cases with asthma were asked to complete the asthma questionnaires and receive physical examination, and then according to the familial predisposition divided into two groups to compare atopic disease incidence, asthma severity and the level of serum IgE （TIgE） and Dust mite specificity IgE（DIIgE）. Result Positive familial predisposition group, the attack rate of atopic disease in children was 81.15 %, had significant difference than negative family predisposition group 45.74 % （ P 〈 0.05） ; positive family predisposition group, TIgE of asthma children was 768.40 ± 524.26IU/mL, had significant difference than negative family predisposition group 597.16 ± 565.38 IU/mL （ P 〈 0.05） ; positive family predisposition group, DIlgE of asthma children was 62.35 ± 51.14kua/L, hadn＇ t significant difference than negative family predisposition group 59.43 ± 60.77kua/L（ P 〉 0.05） ; positive family predisposition group, the attack rate of severe persistent in children was 10.66%, had significant difference than negative family predisposition group 3.19% （ P 〈 0.05 ）; positive family predisposition group, the attack rate of moderate persistent in children was 30.33%, had significant difference than negative family predisposition children 12.77 % （ P 〈 0.05）; Attack rate of intermittent and mild persistent asthma in two groups hadn＇ t significant difference （P 〉0.05, respectively）. TIgE of severe persistent asthma children was 1326.04 ± 635.48 IU/mL, had significant difference than Non- Severe Persistent 650.05 ± 539.10IU/mL （ P 〈 0.05）. Conclusion Family aggregation of atopy is associated with asthma phenotypes in children： Positive family predisposition of atopy pre - dispose asthma children to atopic disease, and their pathogenetie condition is worse, TIgE level is higher.