摘要
目的研究survivin在结肠癌发生、发展中的作用及其与p53表达的关系。方法应用免疫组化SP法检测survivin、p53在32例正常结肠黏膜组织、96例结肠癌组织中的表达。结果survivin在结肠癌组织中的阳性表达显著高于正常结肠黏膜组织(P<0.01),结肠癌浸润浆膜层组的survivin阳性表达明显高于浸润肌层组(P<0.05),结肠癌伴淋巴结转移组的survivin阳性率显著高于无淋巴结转移组(P<0.05),survivin表达与结肠癌的Dukes分期密切相关(P<0.05),p53阳性组的survivin阳性表达明显高于p53阴性组(P<0.01)。结论survivin可作为结肠癌的诊断标记物,检测结肠癌组织中survivin的表达可作为判断结肠癌转移及预后的参考指标。在结肠癌组织中survivin的表达与p53的表达密切相关,survivin和p53在结肠癌的发生发展过程中起协调作用。
Objective To study the expression of survivin and its relationship with expression of p53 in colon carcinoma. Methods The expression of survivin and p53 was studied by immunohistochemical technique （S-P method） in 32 cases of normal colon mucosa and 96 cases of colon carcinoma. Results The survivin expression rate of colon carcinoma was significant higher than that of normal colon mucosa （P〈0.01）. The expression of survivin was associated with infihration degree of colon carcinoma （P〈0.05）.The expression rate of survivin in colon carcinoma with lymph node metastasis was significant higher than those without lymph node metastasis （P〈0.05）. Conclsions The expression of survivin can be used as markers for diagnosis of colon carcinoma.The expression of survivin can be regarded as valuable indicators for evaluating biological behavior and the prognosis of colon carcinoma. Survivin expression was strongly associated with p53 expression in colon carcinoma.
出处
《当代医学》
2009年第3期30-32,共3页
Contemporary Medicine
