摘要
目的研究Ach的代谢在IMS发生过程中所起的作用,以探讨IMS的发病机理。方法在用甲胺磷染毒制作肌无力模型,用碱性羟胺比色法测量其隔肌和腓肠肌Ach含量。结果实验一大鼠甲胺磷染毒后12h、24h肌肉乙酰胆碱含量明显低于正常对照组,实验二低肌力组大鼠腓肠肌Ach含量明显低于高肌力组大鼠腓肠肌Ach,两者含量有显著性差异。结论大鼠急性甲胺磷中毒时,肌肉的Ach含量有一过性下降。神经末梢Ach含量下降有可能造成在神经冲动到达时,神经末档释放Ach减少,从而导致肌无力的出现。
Objective To study the mechanism of myasthenia following acute organophate poisinong.Methods Adult SD rats were made by injection of methamidophos,the acetylcholine levels in blood and museule were measured by using basic hydroxylamine chomatmetry. Results The control group has significant difference of the acetycholine levels with the poisoned group of the 12th hour group and the poisoned group of the 24th hour group.Conclusion The actylcholine levels in lateral gastrocnemius muscles of acute methmidphos intoxicated rats possibly play an inportant role in myasthenia rats.
出处
《当代医学》
2009年第3期37-39,共3页
Contemporary Medicine
关键词
乙酰胆碱
隔肌
腓肠肌
甲胺磷
肌无力
acetycholine
lateral gastrocnemius muscles
diaphragm muscles
methmidph
