摘要
以青霉素G钾为原料,采用过氧乙酸作氧化剂合成青霉素G亚砜酸,收率可达97.3%。实验证实,将青霉素G钾干粉加入18%过氧乙酸溶液可得最佳收率。反应结束后,用稀硫酸调pH值至1.5时,青霉素G亚砜酸从反应液中直接结晶析出。
Penicillin G sulfoxide was synthesized with penicillin G potassium salt as starting material and oxidized by peracetic acid, with yield of 97.3%. Results showed that the optimal yield was obtained by adding penicillin G potassium salt to 18% peracetic acid. Penicillin G sulfoxide can be crystallized directly from the solution by adjusting to pill. 5 wath dilute sulfuric acid.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2009年第2期90-92,共3页
Chinese Journal of Antibiotics
基金
吉林省科技厅科学基金资助项目(20050307-2)
关键词
青霉素G钾
过氧乙酸
青霉素G亚砜酸
Penicillin G potassium salt
Peracetic acid
Penicillin G sulfoxide