摘要
比较了D4006、AB-8、NKA-9、D301T、D296R、D315和001×14.5等7种大孔树脂对灰黄霉素提取液的脱色效果。静态吸附实验结果表明,D301T型树脂对灰黄霉素提取液具有较好的脱色效果和较低的灰黄霉素损失率。该树脂对灰黄霉素提取液脱色的适宜操作条件为:操作温度35℃,pH5.0～6.0,吸附平衡时间20min,提取液处理量为50ml时的树脂适宜添加量为3g。动态吸附适宜流速为3ml/min。树脂吸附后可用1mol/L的NaOH溶液进行洗涤再生。灰黄霉素提取液脱色后经结晶所得灰黄霉素样品质量符合药典要求。
Deeolorization capacity of D4006, AB-8, NKA-9, D301T, D296R, D315 and 001 ×14.5 macroporous resins for griseofulvin extract were investigated. The results of static adsorption tests showed that macroporous resin D301T had higher decolorization capacity and lower griseofulvin loss ratio. The optimum conditions of D301T resin for decolorization were as follows： extract volume, 50ml; resin mass, 3g; adsorption equilibrium time, 20 min; operating temperature, 35℃ ; pH 5.0 - 6.0. The appropriate flow rate of dynamic state adsorption was 3ml/ rain. Used resin can be regenerated by washing with lmol/L NaOH. The griseofulvin crystals after decolorization comply with the pharmacopeia specification.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2009年第2期93-96,共4页
Chinese Journal of Antibiotics
关键词
灰黄霉素
脱色
大孔树脂
吸附
Griseofulvin
Decolorization
Macroporous resin
Adsorption
