扬中市居民饮水及农药使用与食管鳞癌关系的研究

A Study on the Relationship of Drinking Water and Pesti-cides Using and Esophageal Squamous Cell Cancer in Yangzhong County,Jiangsu Province

[目的]探讨江苏省扬中市居民饮水及农药使用对食管鳞癌发生的影响。[方法]采用以人群为基础的病例对照研究方法,对扬中市350例食管鳞癌患者和408例按照性别和年龄进行频数匹配的正常对照进行标准化问卷调查,在控制性别、年龄、吸烟和饮酒等潜在混杂因素后,运用非条件Logistic回归方法分析当地居民饮水及农药使用与食管鳞癌的关系。[结果]既往有直接饮用未处理的河沟水史(OR=1.79,95%CI:1.23～2.61)、居住地周围有水污染相关企业(OR=1.58,95%CI:1.10～2.25),以及经常使用农药(OR=1.70,95%CI:1.24～2.32)尤其是有机氯农药(OR=2.55,95%CI:1.67～3.91)与食管鳞癌发病危险有关。[结论]饮用污染水和农药使用可能与当地居民食管鳞癌高发有关。

[Purpose] To investigate the relationship of drinking water and pesticides use with esophageal squamous cell cancer in Yangzhong county, Jiangsu province. [Method] A populationbased case-control study was designed. Three hundred and fifty cases and 408 controls frequently matched with gender and age in Yangzhong county were investigated by standardized questionnaires. After adjusted by gender, age, alcohol and tobacco consuming, unconditional logistic regression model was used to test the relation between esophageal squamous cell cancer risk and drinking water and pesticides use. [Results] Untreated river water （OR=1.79,95%CI： 1.23-2.61）, living neighboring to factories producing polluted waster （OR=1.58, 95%CI： 1.10-2.25） and frequently pesticides use（OR= 1.70, 95%CI：1.24-2.32）, especially organochlorine （OR=2.55, 95%CI：1.67-3.91） were found to be potential risk factors for esophageal squamous cell cancer. [Conclusions] Polluted drinking water and pesticides use might be risk factors for esophageal squamous cell cancer.