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乳腺癌新辅助化疗对bag-1、bcl-2表达的影响

Impact of Neoadjuvant Chemotherapy on Expression of bag-1 and bcl-2 in Breast Cancer
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摘要 [目的]探讨在乳腺癌新辅助化疗中bag-1,bcl-2表达变化的意义。[方法]采用免疫组化SABC法观察了66例乳腺癌新辅助化疗前后bag-1和bcl-2的表达。[结果]新辅助化疗前后bag-1表达有16例发生变化,其中13例由阳性变为阴性,3例由阴性变为阳性。新辅助化疗前后bag-1表达差异有统计学意义。新辅助化疗前后bcl-2表达状态有9例发生变化,其中6例由阳性变为阴性,3例由阴性变为阳性,新辅助化疗前后bcl-2表达无明显差异。[结论]新辅助化疗对bcl-2表达状态无显著性影响,而能显著降低bag-1的表达,bag-1在新辅助化疗机制中可能起重要作用。
作者 贠军 王廷 王辉 易军 王岭 姚青
机构地区 第四军医大学西京医院
出处 《中国肿瘤》 CAS 2009年第2期159-161,共3页 China Cancer
关键词 乳腺肿瘤 新辅助化疗 BAG-1 BCL-2 免疫组织化学
分类号 R737.9 [医药卫生—肿瘤]
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参考文献9

  • 1Early Breast Cancer Trialists'Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival :an overview of the randomised trials[J]. Lancet, 2005, 365 (9472):1687-1717.
  • 2Charfare H, Limongelli S, Purushotham AD. Neoadjuvant chemotherapy in breast cancer[J]. Br J Surg, 2005, 92( 1 ): 14-23.
  • 3Bear HD, Anderson S, BrownA, et al. The effect on tumor response of adding sequential preoperative docetaxel to preoperative doxorubicin and cyclophosphamide:preliminary results from National Surgical Adjuvant Breast and Bowel Project Protocol B-27[J]. Clin Oncol, 2003, 21(22): 4165-4174.
  • 4Tang SC. BAG-1, an anti-apoptotic tumour marker[J]. IUBMB Life, 2002, 53(2):99-105.
  • 5Yang X, Pater A, Tang SC. Cloning and characterization of the human BAG-1 gene promoter: upregulation by tumor-derived p53 mutants[J]. Neogene, 1999, 18(32):4546- 4553.
  • 6Schmidt U, Wochnik GM, Rosenhagen MC, et al. Cloning and characterization of the human BAG-1 gene promoter: upregulation by tumor-derived p53 mutants [J]. J Biol Chem, 2003, 278(7):4926-4931.
  • 7王鲁建,孙丽梅,孙利敏,董春玲.凋亡和相关蛋白bcl-2在肺癌组织中的表达及对预后的影响[J].中华肿瘤防治杂志,2006,13(4):290-293. 被引量：10
  • 8Takahashi N, Yanagihara M, Ogawa Y, et al. Down regulation of Bcl-2 interacting protein BAG-1 confers resistance toanti cancer drugs[J]. Biochem Biophys Res Commun, 2003, 301(3): 798-803.
  • 9范宇,傅西林,王颖,郎荣刚,于泳.乳腺癌bcl-2表达与患者预后相关因素关系的研究[J].中国肿瘤临床,2002,29(3):160-163. 被引量：9

二级参考文献8

  • 1Mieda J,Ohaki Y,Oguro T,et al.Breast cancer with neuroendocrine differentiation detected by unique staining pattern of neoplastic cells in hercep test[J].J Nippon Med Sch,2004,71(3):203-208.
  • 2Kerr J F,Wyllie A H,Currie A R.Apoptosis:a basic biological phenomenon with wide-ranging implications in tissue kinetics[J].Br J Cancer,1972,26(4):239-257.
  • 3Ohmori T,Podack ER,Nishio K,et al.Apoptosis of lung cancer cells caused by some anti-cancer agents (MMC,CPT-11,ADM) is inhibited by bcl-2[J].Biochem Biophys Res Commun,1993,192(1):30-36.
  • 4Tsujimoto Y,Finger L R,Yunis J,et al.Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation[J].Science,1984,226(4678):1097-1099.
  • 5Lu Q L,Poulsom R,Wong L,et al.Bcl-2 expression in adult and embryonic non-haematopoietic tissues[J].J Pathol,1993,169(4):431-437.
  • 6Haldar S,Negrini M,Monne M,et al.Down-regulation of bcl2 by p53 in breast cancer cells[J].Cancer Res,1994,54(8):2095-2097.
  • 7Miyashita T,Krajewski S,Krajewska M,et al.Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo[J].Oncogene,1994,9(6):1799-1805.
  • 8Dr. Daniel R. Ciocca,Richard Elledge. Molecular markers for predicting response to tamoxifen in breast cancer patients[J] 2000,Endocrine(1):1～10

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中国肿瘤
2009年 第2期

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