摘要
横纹肌肉瘤是儿童最常见恶性软组织肉瘤，其可能来源于分化异常的骨骼肌。横纹肌肉瘤具有高度的非整倍体水平，其发生发展与PAX—FOX01基因融合、癌基因、抑癌基因、多药耐药基因等密切相关。分子生物学方面的研究有助于临床诊断及治疗。本文综述了近年来横纹肌肉瘤分子生物学的研究进展。
Rhabdomyosareoma,the most common pediatric soft tissue sareoma, eomes from deregulation of the skeletal myogenesis. Rhabdomyosareoma is in a high degree of aneuploidy. The initiation and development of rhabdomyosarcoma are correlated with PAX-FOXO1 fusion gene,oneogene, anti-oncogene and muhidrug resistanee gene. Researches of rhabdomyosareoma are helpful to diagnosis and treatment. This article reviewed the molecular biology of rhabdomyosareoma.
出处
《医学综述》
2009年第4期514-517,共4页
Medical Recapitulate
基金
国家自然科学基金面上项目(30672359)
