受体酪氨酸激酶在肿瘤血管新生中的作用

Effect of Receptor Protein-tyrosine Kinases in Tumor Angiogenesis

血管新生是一个非常复杂的过程，它在正常发育和多种疾病包括肿瘤新生血管形成、局部缺血修复、创伤愈合的病理生理中扮演了关键性的角色，其机制仍不清楚。研究已证明有3个受体蛋白酪氨酸激酶家族在血管新生中发挥了重要的作用，包括血管内皮生长因子受体（VEGFR）、Tie和Ephfin受体。VEGF／VEGFR系统在调节血管新生中研究最多，也最为重要。它刺激内皮细胞增殖，增加血管通透性，诱导实体瘤内部新生淋巴管形成；Angiopoietin／Tie系统调节着血管的成熟和稳定；Ephfin／Eph系统以不同的方式，参与肿瘤的发生及恶性进展。

Angiogenesis is a highly complex process that plays a critical role in normal development and in the pathophysiology of multiple disease processes, including tumour neovascul-arization, ischaemic recovery and wound healing, the mechanisms remain unelearo. Extensive studies have been carried out, three families of receptor protein-tyrosine kinases play pivotal roles in angiogenesis. The vascular endothelial growth factor （VEGF）/vaseular endothelial growth factor receptor （VEGFR） family in the research of regulating blood vessel neogenesis is the most studied and most important regulator of vascular development. It activate endothelioeyte proliferation, and increase permeability in the vascular endothelial cell, induce the form of new ab- sorbent vessels in solid tumo. The Angiopoietin/Tie system controls vessel maturation and quiescence, while the Ephrin/Eph system participates tumorigenesis and proliferation in different ways.