氩氦刀联合全身化疗治疗中晚期非小细胞肺癌的Meta分析

Meta-analysis of cryotherapy combined with chemotherapy for advanced non-small cell lung cancer

目的:系统评价氩氦刀联合全身化疗治疗中晚期非小细胞肺癌(NSCLC)患者的可行性和应用价值。方法:采用Cochrane系统评价方法,系统检索PUBMED、EBMASE、OVID、CNKI等数据库及相关试验的参考文献,评价纳入研究的方法学质量,采用RevMan 5.0软件进行Meta分析。共纳入4个研究,423例中晚期NSCLC患者,分为氩氦刀联合全身化疗组(188例)和氩氦刀组(235例)。结果:氩氦刀组与氦刀联合全身化疗组比较,治疗NSLCL近期有效率合并OR值为2.09,95%CI为[1.40～3.14],1年生存率合并RR为1.30(0.98,1.72)。氩氦刀联合全身化疗的近期疗效与氩氦刀比较,可提高近期临床缓解率,但不能改善1年生存率。结论:氩氦刀联合全身化疗治疗中晚期NSCLC患者可提高近期疗效,但远期疗效有待观察。需多中心大样本随机对照试验进一步证实。

Objective ： To assess the feasibility and application value of cryotherapy combined with chemotherapy for the treatment of advanced non-small cell lung cancer （ NSCLC ）. Methods ： We retrieved the clinical trials and references relevant to cryotherapy combined with chemotherapy and cryotherapy alone in the treatment of advanced NSCLC in the databases of PUBMED, EBMASE, OVID and CNKI, et al, and evaluated the methodological quality of the included trials. Meta-analyses were conducted with the Revman 5.0 software. Four studies and 423 cases of advanced NSCLC were included. Results ： The pooled OR of the effectiveness of the combined therapy was 2.09, the 95% CI was 1.40 -3.14 and the RR of 1-year survival was 1.30 （0.98, 1.72）. Compared with cryotherapy alone, the combined therapy achieved a higher rate short-term efficacy but could improve the rate of 1-year survival. Conclusion：Cryotherapy combined with chemotherapy has a better short-term effect than cryotherapy alone on advanced NSCLC, but its long-term efficacy remains to be further investigated.