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甘露糖结合凝集素与炎性肠病相关性的研究进展 被引量：3

Association of mannan-binding lectin with inflammatory bowel disease
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摘要 甘露糖结合凝集素(MBL)属于凝集素家族,是机体先天性免疫的重要成分,有激活补体系统、调理吞噬等作用,并与许多免疫相关性疾病有关。炎性肠病包括溃疡性结肠炎和克罗恩病,目前普遍认为其发病机制与自身免疫损害密切相关。近年研究表明,MBL基因的多态性导致了其血清水平的个体差异,且与炎性肠病的发病率、临床症状、病程等具有相关性。文中综述了MBL及其与炎性肠病间相关性的研究进展。 Mannan binding lectin （MBL） is an innate immune mediator belonging to the collectin family known to bind to the surface of many viruses, bacteria and fungi. Many researches show that MBL is associated with many autoimmune diseases. Inflammatory bowel diseases （IBD） including ulcerative colitis and Crohn＇s disease are related with innate individual immunity. This article reviews the recent researches on the association of MBL with IBD.
作者 吴瑛 汪芳裕
机构地区 南京大学医学院临床学院(南京军区南京总医院)消化内科
出处 《医学研究生学报》 CAS 2009年第2期217-220,共4页 Journal of Medical Postgraduates
基金 南京军区医药卫生科研基金资助项目(批准号:07M076)
关键词 甘露糖结合凝集素 炎性肠病 甘露糖相关丝氨酸蛋白酶 基因多态性 Mannan-binding lectin Inflammatory bowel disease MBL-assoeiated serine protease Gene polymorphism
分类号 R574 [医药卫生—消化系统]
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参考文献26

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二级参考文献56

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共引文献12

同被引文献18

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医学研究生学报
2009年 第2期

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