摘要
目的：探讨FEZ1／LZTS1基因在喉鳞状细胞癌中的表达缺失及其与临床病理的关系。方法：采用逆转录聚合酶链反应（RT—PCR）法，分析50例原发性喉癌组织和癌旁组织中FEZ1／LZTS1基因的表达情况。结果：FEZ1／LZTS1基因在癌旁组织中表达率明显高于喉癌组织（P〈0．01）；在喉癌组织中FEZ1／LZTS1基因阳性表达率随其病理分级、临床分期升高而降低（P〈0．01），而与患者年龄、性别和原发灶部位无关。结论：FEZ1／LZTS1基因的表达缺失可能对LSCC的发生发展起重要作用，是LSCC发展中的重要分子事件。
Objective：To investigate expression of FEZI/LZTSI gene and relationship between lost ex- pression of this gene and clinicopathologic features of laryngeal squamous cell carcinoma （LSCC）. Methods： The expressions of FEZ1/LZTSIgene in carcinoma and normal tissues in 50 patients with primary LSCC were analyzed by the RT- PCR method. Results ：The expression of FEZ1/LZTS1 in normal tissues were significant higher than those in LSCC tissues （P 〈0.01 ）. With increasing of pathologic grades and clinical TNM stages, the positive expression rates of FEZI/LZTS1 gene in LSCC tissues degraded gradually （P 〈 0.01 ） , which were not relative to the patients＇ ages, genders and positions of primary lesions. Conclusions：The loss expression of FEZ1/LZTS1 gene may play an important role in the development of LSCC and is a crucial molecular event.
出处
《解剖与临床》
2009年第1期21-23,共3页
Anatomy and Clinics
