甲状腺干细胞及其与甲状腺肿瘤干细胞的关系
Thyroid stem cells and thyroid tumor stem cells
摘要
甲状腺干细胞是存在于甲状腺组织内具有自我更新及增殖分化潜能的细胞。甲状腺肿瘤干细胞是甲状腺肿瘤组织中与甲状腺干细胞相似的细胞,是甲状腺肿瘤发生发展的细胞来源。研究表明,甲状腺干细胞是甲状腺肿瘤干细胞的重要来源,其恶变时所处的分化阶段对甲状腺肿瘤的恶性程度有重要影响。
Thyroid stem cells have potential of self-renewing, proliferation and differentiation in thy- roid. Thyroid tumor stem cells similar to thyroid stem cells in thyroid are origin of thyroid tumor cells. Thyroid stem cells are important source of thyroid tumor stem cells and stages of differentiation have important influence on malignancy of thyroid tumor.
出处
《国际肿瘤学杂志》
CAS
2009年第2期121-123,共3页
Journal of International Oncology
关键词
干细胞
肿瘤干细胞
甲状腺肿瘤
Stem cells
Neoplastic stem cells
Thyroid neoplasms
参考文献16
-
1Preto A, Cameselle-Teijeiro J, Moldes- Boullosa J, et al. Telomerase expression and proliferative activity suggest a stem cell role for thyroid solid cell nests. Mod Pathol, 2004, 17(7) : 819-826.
-
2Burstein DE, Nagi C, Wang BY, et al. Immunohistochemical detection of p53 homolog p63 in solid cell nests, papillary thyroid carcinoma, and hashimoto' s thyroiditis : A stem cell hypothesis of papillary carcinoma nncogenesis. Hum Pathol, 2004, 35(4) :465-473.
-
3Sarosi G, Brown G, Jaiswal K, et al. Bone marrow progenitor cells contribute to esophageal regeneration and metaplasia in a rat model of Barrett's esophagus. Dis Esophagus, 2008, 21 ( 1 ) :43-50.
-
4Koide Y, Morikawa S, Mabuchi Y, et al. Two distinct stem cell line- ages in murine bone marrow. Stem Cells, 2007, 25(5) :1213-1221.
-
5Thomas T, Nowka K, Lan L, et al. Expression of endoderm stem cell markers: evidence for the presence of adult stem cells in human thyroid glands. Thyroid, 2006, 16(6) :537-544.
-
6Lan L, Cui D, Nowka K, et al. Stem cells derived from goiters in a-dults form spheres in response to intense growth stimulation and require thyrotropin for differentiation into thyrocytes. J Clini Endocrinol Metabo, 2007, 92(9):3681-3688.
-
7Hoshi N, Kusakabe T, Taylor B J, et al. Side population cells in the mouse thyroid exhibit stem/progenitor cell-like characteristics. Endocrinology, 2007, 148(9) :4251-4258.
-
8Wu C, Alman BA. Side population cells in human cancers. Cancer Lett, 2008, 268(1):1-9.
-
9Mitsutake N, Iwao A, Nagai K, et al. Characterization of side population in thyroid cancer cell lines. Endocrinology, 2007, 148 ( 4 ) : 1797 - 1803.
-
10Vasko VV, Saji M. Molecular mechanisms involved in differentiated thyroid cancer invasion and metastasis. Curr Opin Oncol, 2007, 19 (1):11-17.
-
1杨春莲,曹仁贤.甲状腺肿瘤干细胞及其生物学特性的研究进展[J].中国医学创新,2013,10(30):159-162.
-
2潘敦,张澍,李宗芳.肿瘤干细胞的研究进展[J].国际外科学杂志,2006,33(4):283-286. 被引量:1
-
3王椋,曲学彬,赵春华.慢性粒细胞白血病肿瘤干细胞的免疫调节功能[J].基础医学与临床,2011,31(4):404-408. 被引量:2
-
4刘永冬,王乐冰,贺媛媛,熊姚,王良海,侯隽.HBV与肝癌干细胞研究进展[J].农垦医学,2016,38(1):41-44. 被引量:1
-
5兰玲,崔岱,施秉银,张国英,邓微,王红,陈海翎,邓丽丽.人甲状腺成体干细胞的分离、培养及诱导分化[J].中华医学杂志,2012,92(12):806-810. 被引量:5
-
6郑进方,梁力建.肝干细胞与肝癌关系的研究进展[J].国外医学(外科学分册),2005,32(6):412-416. 被引量:2
-
7肿瘤干细胞中特定蛋白可助防止病情复发[J].中华生物医学工程杂志,2008,14(4):277-277.
-
8郑仁东,刘超.甲状腺干细胞的研究进展[J].国际内分泌代谢杂志,2015,35(3):205-207. 被引量:1
-
9第二届国际肿瘤干细胞学术会议征文通知[J].中华肿瘤杂志,2009,31(5):370-370.
-
10第二届国际肿瘤干细胞学术会议征文通知[J].中华肿瘤杂志,2009,31(6):409-409.