红色毛癣菌病患者血清NO与iNOS表达的实验研究

Expression of NO and iNOS in the sera of patients with trichophytosis rubrum

目的：测定红色毛癣菌病患者血清中一氧化氮（NO）、诱生型一氧化氮合酶（iNOS）的表达。方法：应用硝酸还原酶法和分光光度法检测30例手足癣，35例甲真菌病患者和20名正常对照者血清中NO、iNOS的水平。结果：与正常对照组相比较，红色毛癣菌病患者外周血NO及iNOS血清水平明显降低（P〈0．01）。手足癣组与甲真菌病组之间NO及iNOS相互比较，差异无统计学意义（P〉0．05）。结论：红色毛癣菌病患者机体的免疫防御机制不能有效发挥其抗真菌效应，这可能是导致感染易反复和病程迁延的原因之一。

Objective： To measure the serum levels of NO and iNOS in patients with trichophytosis rubrum. Methods： Nitrate reductase and spectrophotometry methods were used to detect the levels of NO and iNOS in the se-ra of 30 patients with tinea pedis, 35 patients with onychomycosis and 20 normal controls. Results： Campared to normal control, the levels of NO and iNOS were significantly depressed（ P 〈 0.01 ） in the patients with trichophytosis rubrum. There was no significant difference in the levels of NO and iNOS between tinea pedis group and onychomy- cosis group （ P 〉 0.05）. Conclusion： The immunity of the patients can not effectively defense against trichophytosis rubrum, which may be one of the causes for the recurrent infection and the prolonged course of the infection.