女性下生殖道解脲脲原体感染的检测及与其他感染相关分析

Detection of Ureaplasma urealyticum （UU） infection in female low genital tract and the relationship to other sexual transmitted infections

目的：了解海口地区解脲脲原体（UU）感染情况及其与四种常见女性阴道炎、宫颈炎的关系。方法：对606例女性就诊患者采样进行淋病、阴道念珠菌病、滴虫性阴道炎、细菌性阴道病病原体和UU进行检测。结果：UU总感染率为51．16％（310／606）；606例患者中混合感染占210例，其中UU感染135例占混合感染检出率的64．29％；淋病、阴道念珠菌病、滴虫性阴道炎时宫颈UU检出率差异无统计学意义（P〉0．05）；细菌性阴道病时宫颈UU检出率差异有统计学意义（P〈0．01）；UU检测≥10^4ccu／mL者，其单独感染率（67．1％）较UU检测菌量〈104ccu/mL者（45．4％）高，混合感染率（32．9％）较UU检测菌量〈10^4ccu／mL者（54．6％）低，差异有显著性（P〈0．01）。结论：海口地区女性就诊患者UU感染及其与阴道炎、宫颈炎混合感染相当普遍；细菌性阴道病可能是女性UU感染的诱因和易感因素之一。

Objective： To determine the prevalence of Ureaplasma urealyticum （UU） infection and to associate the infection with other STIs in women of Haikou District. Methods： Gonorrhea, candidal vaginitis, trichomonal vaginitis （TV）, bacterial vaginosis （BV） and UU were detected respectively in 606 female patients. Results： Out of the 606 female patients, 310 were found to be inflected with UU （51.16%） and the mixed infections were in 210 patients, of which infections with other STIs aceounted for 64.29 % （135/210）. There was no significant difference in the detection of UU among the patients with gonorrhea, candidal vaginitis or TV （ P 〉 0.05）, but the detection rate in BV patients was significantly different （P 〈 0.01 ）. The patients with high quantity of UU （≥10^4 ccu/mL） were more likely to be inflected with UU infection alone compared with the patients with mixed infections （ P 〈 0.01 ）. Conclusion： UU infection and mixed infections with vaginitis and cervicitis are common in Haikou District. Bacterial vaginitis may be one of the causal and predisposing factors for UU inflection. The pathogenicity of UU may be related to the quantity of the bacterium.