国产阿立哌唑与奋乃静治疗精神分裂症的对照研究

A Controlled Study on Schizophrenia Treated with Aripiprazole and Perphenazine.

目的以奋乃静为对照,探讨国产阿立哌唑治疗精神分裂症的疗效和安全性。方法将80例精神分裂症患者随机分为两组,阿立哌唑研究组和奋乃静对照组各40例,于治疗前和治疗后1、2、4、6、8周末进行PANSS评分和TESS评价疗效。结果阿立哌唑组和奋乃静组之间疗效无明显差异。在认知因子和阴性症状减分率方面,阿立哌唑组与奋乃静组有明显性差异。阿立哌唑组主要不良反应有轻度头昏、瞌睡、体重增加等。结论阿立哌唑是一种安全有效的抗精神药物,特别是在改善认知功能和阴性症状方面有较好的临床效果。

Objective To study the efficacy and safety of aripiprazole in treating schizophrenia by using perphenazine as a control.Methods 80 cases with schizophrenia were randomly divided into experimental（aripiprazole） and controlled（perphenazine） group.Each group had 40 cases.PANSS and TESS scales were used to measure effectiveness and safety before treatment and at the end of week 1,2,4,6 and 8,respectively.Results There were no significant differences in effectiveness between two groups.However,significant differences were found between two groups in the score reduce rates about cognitive factors and negative symptoms.The main side effects in Aripiprazole group were mild dizziness,drowsiness and weight gain etc.Conclusion Aripiprazole was an effective and safe neuroleptic.Specifically,it had better clinical effect in improving cognitive function and negative symptoms.