新诊断2型糖尿病短期胰岛素强化治疗的临床观察被引量：1

下载PDF

导出

摘要对新诊断、未曾治疗过的T2DM患者给予1～3个月短期胰岛素强化治疗,随访观察胰岛β细胞功能变化及对血糖长期控制的影响。结果β细胞功能获得显著改善(P<0.01);停药后血糖维持稳定3月-3年不等。结论对新诊断T2DM患者短期胰岛素强化治疗能显著改善胰岛β细胞功能。

作者王晓敏孟作龙杨惠珍王玉梅安思芹

机构地区兰州大学附属白银医院内分泌科

出处《实用糖尿病杂志》 2009年第1期28-29,共2页 Journal of Practical Diabetology

关键词 2型糖尿病(T2DM) 胰岛素强化治疗 Β细胞功能血糖糖化血红蛋白

分类号 R587.1 [医药卫生—内分泌] R512.91 [医药卫生—内科学]

引文网络
相关文献

参考文献5

1Purrllo F, Rabuazza AM, Metabolic factors that affect beta - cell function and surrival. Diabet Nutr metab 2000 ; 13:84 - 91.
2张建功,程桦,黎峰,黄秀琼,李芳萍,陈黎红,严励.血糖控制对2型糖尿病患者胰岛β细胞功能及胰岛素敏感性的影响[J].中华内分泌代谢杂志,2003,19(1):21-24. 被引量：63
3纪立农.“β-细胞休息”概念及其在糖尿病防治中的应用[J].国外医学（内分泌学分册）,2003,23(3):180-181. 被引量：174
4祝方,纪立农,韩学尧,朱宇,张红杰,周翔海,陈静,蔡晓陵,张明霞.短期胰岛素强化治疗诱导初诊2型糖尿病患者血糖长期良好控制的临床试验[J].中国糖尿病杂志,2003,11(1):5-9. 被引量：856
5李延兵,翁建平,许雯,陈小华,廖志红,姚斌,邓婉萍,欧香忠,胡国亮.短期持续胰岛素输注治疗对初诊2型糖尿病患者胰岛β细胞功能的影响[J].中国糖尿病杂志,2003,11(1):10-15. 被引量：777

二级参考文献33

1Weyer. Dificiency in AIR predict IGT and Type 2 diabetes. Diabetes Care, 2001,24 : 89-94.
2Haffner SM, Miettinen H, Gaskill SP, et al. Decreased insulin secretion and increased insulin resistance are independently related to the 7-year risk of NIDDM in Mexican-Americans. Diabetes, 1995,44: 1386-1391.
3Bruce DG, Chisholm DJ, Leonare H, et al. Physiological importance of deficiency in early prandial insulin secretion in non-in-sulin-dependent diabetes. Diabetes, 1988,37: 736-743.
4Bruttomesso D, Pianta A, Mari A, et al. Restoration of early rise in plasma insulin levels improves the glucose tolerance of type 2 diabetic patients. Diabetes, 1999,48: 99-105.
5Ilkova H, glaser B, Tunckale A, et al. Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients by transient intensive insulin treatment. Diabetes Care, 1997,20:1353-1356.
6Walton C, Godsland IF, Proudler AJ, et al. Effect of body mass index and fat distribution on insulin sensitivity, secretion, and clearance in nonobese healthy men. J Clin Endocrinol Metab,1992,75: 170-175.
7Purrello F, Rabuazza AM. Metabolic factors that affect betacell function and survival. Diabet Nutr Metab, 2000, 13: 84-91.
8Sivitz WI. Lipotoxieity and glueotoxieity in type 2 diabetes. Effects on development and progression. Postgrad Med, 2001,109: 55-59,63-64.
9Lenhard M J, Reeves GD. Continous subcutaneous insulin infusion: a comprehensive review of insulin pump therapy. Arch Intern Med,2001,161: 2293-2300.
10Dupuy O, Mayaudon H, Palou M, et al. Optimized transient insulin infusion in uneontrolled type 2 Diabetes : Evaluation of a pragmatie attitude. Diabet Med, 2000,26 : 371-375.