部分脾动脉栓塞术治疗肝炎肝硬化脾功能亢进

Partial splenic embolization in the treatment of hypersplenism due to post hepatitis cirrhosis

门静脉高压症常继发于肝硬化,主要表现为脾肿大,侧支循环的建立和腹水,同时亦可引起脾功能亢进。众多临床研究证明,部分性脾栓塞是治疗门静脉高压症的一种有效方法。本文总结近年来门脉高压症、脾肿大的发病机制,分析门脉高压与脾脏肿大的血流动力学关系,综述部分脾动脉栓塞治疗肝炎肝硬化脾功能亢进的原理和临床应用现状,并评价其疗效。

Portal hypertension（PH）frequently follows upon cirrhosis. Its main clinical manifestations include splenomegaly, collateral circulation formation, ascites and hypersplenism. A large number of clinical studies has shown that partial splenic embolization is an effective and safe technique for the treatment of PH. This paper aims to summarize the recent advances in clarifying the PH and splenomegaly mechanism, to analyze the relation between PH and splenic hemodynamics, to discuss the principles of partial splenic embolization for the treatment of hypersplenism caused by post hepatitis cirrhosis, and to make an overlook of the partial splenic embolization technique in the clinical practice at present. （J Intervent Radiol, 2009, 18： 155-158）