凋亡抑制蛋白XIAP、Survivin与白血病

Inhibitor of apoptosis proteins XIAP, survivin and leukemia

白血病是造血系统的恶性增生性疾病。其特点为造血组织中某一血细胞系统过度增生，进入血流并浸润到各组织和器官，从而引起一系列临床表现。近年来对白血病的研究发现其与细胞凋亡有关。凋亡抑制蛋白XIAP、Survivin的抗凋亡作用尤其受到重视，研究发现其在肿瘤发生及耐药中具有重要作用。就其生物学特性及其在白血病中的表达和意义进行综述。

Leukemia is a malignant hyperplasia disease of hematopoietic system. It is characterized that a certain blood cell system proliferates, gets into blood streaming, infiltrates each organism and apparatus and arouse a series of clinical manifestation. In recent years the study of leukemia has discovered that it was correlated with apoptosis of the cells. The roles of XIAP and survivin in apoptosis inhibition have been especially paid attention. It is discovered that they play major roles in the genesis and resistance to chemotherapeutical drug of tumors. We summarize the biological characteristics and the expressions of XIAP and survivin in the children with acute leukemia.