摘要
Claudins是构成上皮细胞和血管内皮细胞紧密连接的一类跨膜蛋白家族,维持紧密连接特有的栅栏和屏障功能。Claudins广泛分布于正常组织和不同肿瘤组织,且存在差异性的表达。近年,在胃癌前病变和胃癌中也发现几种claudins蛋白表达异常,并与预后有关。通过对claudins在胃癌中异常分布和表达的研究,人们能更好得理解胃癌的发生发展机制,从而有利于胃癌的诊断和治疗。
The claudin family of transmembrane proteins plays a critical role in the maintenance of epithelial and endothelial tight junctions,which participates in barrier function and fence function of tight junctions. In addition to distributing in normal tissue, several studies have reported some claudins to be aberrantly altered in several cancers. Recently,the differential expression of several claudins have been found in gastric cancer precursor lesions and gastric cancer, which is also associated with prognosis.
出处
《国际消化病杂志》
CAS
2009年第1期8-10,共3页
International Journal of Digestive Diseases
