期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

同型半胱氨酸和炎症性肠病 被引量：2

Homocysteine and inflammatory bowel disease
下载PDF
导出
摘要 炎症性肠病(IBD)包括溃疡性结肠炎(UC)和克罗恩病(CD),同型半胱氨酸(Hcy)是一种含巯基氨基酸,是甲硫氨酸(Met)去甲基化过程中的产物,多项研究表明IBD患者中Hcy浓度有增高。Hcy可能在IBD的发生发展中起一定作用。 Inflammatory bowel disease（IBD） includes ulcerative colitis（UC） and Crohn＇s disease（CD）. Homocysteine（Hcy） is a kind of amino acids including thiols, a product of the demethylation process of methionine（Met） . Several research have found that the level of Hcy is higher in the IBD patients. Hcy may be associated with IBD.
作者 张丽 陈春晓
机构地区 浙江大学医学院附属第一医院
出处 《国际消化病杂志》 CAS 2009年第1期58-60,共3页 International Journal of Digestive Diseases
关键词 同型半胱氨酸 炎症性肠病 溃疡性结肠炎 克罗恩病 Homocysteine Inflammatory bowel disease Ulcerative colitis Crohn＇s disease
分类号 R574 [医药卫生—消化系统]
  • 相关文献

参考文献24

  • 1Stipanuk MH. Sulfur amino acid metabolism: Pathways for production and removal of homocysteine and eysteine. Annu Rev Nutr, 2004,24:539-577.
  • 2Den Heijer M, Rosendaal FR, Blom HJ, et al. Hyperhomocysteinemia and venous thrombosis: A meta-analysis. Thromb Haemost, 1998,80: 874-877.
  • 3ErzinY, Uzun H, Celik AF , et al. Hyperhomocysteinemia in inflammatory bowel disease patients without past intestinal resections: Correlations with eobalamin, pyridoxine, folate concentrations, acute phase reactants, disease activity, and prior thromboembolie complications. J Clin Gastroenterol,2008 ,42:481-486.
  • 4Roblin X,Germain E, Phelip JM, et al. Factors associated with hyperhomocysteinemia in inflammatory bowel disease: prospective study in 81 patients. Rev Med Interne, 2006, 27:106-110.
  • 5Fernandez Miranda C, Martinez Prieto M, Casis Herce B, et al. Hyperhomoeysteinemia and methylenetetrahydrofolate reductase 677->T and 1298A->C mutations in patients with inflammatory bowel disease. Rev Esp Enferm Dig, 2005 ,97:497-504.
  • 6Papa A, De Stefano V, Danese S, et al. Hyperhomocystcincmia and prevalence of polymorphisms of homocysteine metabolism related enzymes in patients with inflammatory bowel disease. Am J Gastroenterol, 2001,96:2677-2682.
  • 7Mahmood A, Needham J, Prosser J, et al. Prevalence of hyperhomocysteinaemia, activated protein C resistance and pro thrombin gene mutation in inflammatory bowel disease. Eur J Gastroenterol Hepatol ,2005,17:739-744.
  • 8Danese S, Sgambato A, Papa A, et al. Homoeysteine triggers mucosal microvascular activation in inflammatory bowel diease. Am J Gastroenterol, 2005,100:886-895.
  • 9Saibeni S, Cattaneo M, Vecchi M, et al. Liw vitamin B(6) plasma levels, a risk factor for thrombosis, in inflammatory bowel disease: Role of inflammation and correlation with acute phase reactants. Am J Gastroenterol, 2003,98:112-117.
  • 10Miyazono Y, Gao F, Horie T. Oxidative stress contributes to methotrexate-induced small intestinal toxicity in rats. Scand Gastroenterol, 2004.39:1119-1127.

同被引文献15

  • 1Sabiye Akbulut,Emin Altiparmak,Firdevs Topal,Ersan Ozaslan,Metin Kucukazman,Ozlem Yonem.Increased levels of homocysteine in patients with ulcerative colitis[J].World Journal of Gastroenterology,2010,16(19):2411-2416. 被引量：14
  • 2中华医学会消化病学分会炎症性肠病学组.我国炎症性肠病诊断与治疗的共识意见[J].胃肠病学,2012,17:763-781.
  • 3Danese S, Sgambato A, Papa A, et al. Homocysteine trig-gers mucosal microvascular activation in inflammatory bowel dis- ease[J]. Am J Gastroenterol, 2005, 100:886-895.
  • 4Holven KB, Aukrust P, Retterstol K, et al. Increased levels of cre- ative protein and interleukin-6 in hyperhomocysteinemic subjects [J]. Scand J Clin Lab Invest, 2006, 66:45-54.
  • 5Keller L, Surette MG. Communication in bacteria:an ecological and evolutionary perspective [J]. Nat Rev Microbiol, 2006, 4:249-258.
  • 6Papa A, De Sterfano V, Danese S, et al. Hyperhomocysteinemia and prevalence of polymorphisms of homocysteine metabolism re- lated enzymes in patients with in inflammatory bowel disease[J]. Am J Gastroenterol, 2001, 96:2677-2682.
  • 7Mahmood A, Needham J, Prosser J, et al. Prevalence of hyperho- mocysteinaemia,activated protein C resistance and prothrombin gene mutation in inflammatory bowel disease [J]. Eur J Gastroen- terol Hepatol, 2005, 17:739-744.
  • 8朱炳喜,刘元山,陈剑群.细胞因子在大鼠溃疡性结肠炎模型中的表达研究[J].吉林医学,2009,30(19):2227-2229. 被引量：6
  • 9邱洁英,刘光金,杨小金.实验室检测对溃疡性结肠炎患者诊断和评估预后的相关研究[J].实验与检验医学,2010,28(2):153-154. 被引量：7
  • 10蒋益,赵杰,陈小燕,陈立平,雷媛,黄莎,王昌高,易烽明,夏冰.血浆同型半胱氨酸及其代谢酶基因多态性与溃疡性结肠炎的相关性研究[J].中华消化杂志,2010,30(5):312-316. 被引量：4

引证文献2

二级引证文献10

国际消化病杂志
2009年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部