以宿痰伏肺立论治疗支气管哮喘缓解期临床探讨

Clinical study on the treatment for bronchial asthma in remission stage based on the theory of old phlegm in lung

目的以宿痰伏肺理论为依据探讨缓解期支气管哮喘患儿临床疗效的可行性。方法将200例支气管哮喘缓解期患儿分为两组,金龙固本合剂口服观察组和辅舒酮吸入对照组各100例。临床治疗2个月后随访2年,观察患儿疗效和外周血嗜酸性粒细胞计数(EOS),IgG,IgE,T细胞亚群及肺功能的变化。结果治疗前后的自身对照,观察组每年的哮喘复发次数较治疗前明显减少,患儿EOS明显降低,T淋巴细胞亚群CD8明显增加,CD4/CD8细胞比值降低,肺功能明显改善(P<0.05)。结论采用以宿痰伏肺为理论依据研制的金龙固本合剂治疗缓解期支气管哮喘患者临床疗效明显。免疫功能紊乱是引起支气管哮喘反复发作的重要因素,采用固本化痰法运用中医药调节免疫功能,为哮喘缓解期的中医药治疗提供理论依据。

Objective To probe into the feasibility of clinical treatment for bronchial asthma in remission stage based on the theory of old phlegm in lung. Methods Totally 200 cases of bronchial asthma in remission stage were divided into two groups,Jinlong Guben mixture of oral treatment and control groups of with 100 cases in each.Clinical treatment lasting two months there was a 2year followup,and observe the effects in patients,and peripheral eosinophil counts,serum immunoglobulin IgG,IgE,T cell subsets and changes in lung function. Results The frequency of recurrence in the treatment group significantly reduced after treatment;eosinophil count decreased significantly;Tlymphocyte subsets of CD8 increased significantly;CD4/CD8 ratio reduced and lung function improved significantly（P〈0.05）. Conclusion Jinlong Guben mixture,which is made based on the theory of old phlegn in lung,has significant clinical effect in treating patients with bronchial asthma in remission stage.Immunologic dysfunction is the cause of recurrent attack of bronchial asthma.The dysfunction can be improved by TCM in the way of consolidating foundation and clearing sputum,which provides throretical basis for the TCM treatment for asthma in remission stage.