生脉成骨胶囊治疗SARS后早期股骨头无菌性坏死的研究

Study on Shengmaichenggu Capsules in treating patients with premature avascular necrosis of the femoral head(ANFH) after severe acute respiratory syndrome(SARS)

目的利用磁共振(MRI)检查方法观察评价生脉成骨胶囊治疗SARS后早期股骨头无菌性坏死疗效。方法搜集我院2003～2005年SARS后早期股骨头无菌性坏死的患者17例,共29髋,采用MRI检查方法,诊断和追随评价生脉成骨胶囊的疗效。采用Koo等测量方法比较治疗前后骨坏死的角度指数;采用Holman等的测量方法,比较治疗前后坏死面积指数。结果治疗前后骨坏死角度指数、面积指数差异显著(P<0.01,P<0.05);生脉成骨胶囊能够缩小坏死面积,改善骨髓水肿和关节积液,但治疗前后比较无统计学差异。结论生脉成骨胶囊可减小骨坏死的范围,改善骨髓水肿和关节积液。

Objective To evaluate the therapeutic effect of Shengmaichenggu Capsules in treating patients with premature avascular necrosis of the femoral head （ANFH）after severe acute respiratory syndrome （SARS）. Methods 17 patients with premature ANFH after SARS were treated with Shengmaichenggu Capsules. The therapeutic effect was evaluated by measuring the necrotic portion of MRI images （including measuring the index of the necrotic portion angle and area）. Results The difference of the necrotic portion angle between after treatment and before treatment was significant （P 〈 0.01 ） ; The difference of the index of necrotic portion area was significant （P 〈0.05）;The hydrarthrosis and marrow dropsy were all improved after treatment, but there were no significant differences compared with those before treatment respectively （P 〉 0.05）. Conclusion Shengmaichenggu Capsules can diminish the necrotic portion, reduce hydrarthrosis and marrow dropsy.