口服避孕药和妇女高血压发病风险的病例对照研究

Case Control Study of Oral Contraceptives and Onset Risk of Women Hypertension

目的:评价妇女口服避孕药(OC)的使用与高血压发病风险的关系。方法:采用病例对照研究方法,在太仓和如东两地区选择665例高血压病例和665例非高血压对照,用问卷调查和体检的方式对高血压相关因素进行收集和分析。结果:随着OC累积使用时间的增加,妇女患高血压的风险也逐渐增加,有明显的剂量-效应关系(趋势性检验P=0.0001)。调整年龄和地区因素后,当前和既往使用OC≥15年的妇女发生高血压的风险显著增加(P=0.0196,P=0.0038)。Logistic回归分析显示:体质指数、高血压家族史和OC累积使用时间升高均显著增加妇女患高血压的风险,太仓和如东地区服用OC的妇女对高血压的易感性可能存在差异。结论:累积使用OC≥15年显著增加妇女患高血压的风险,影响血压变化的其它危险因素尚需要进一步探讨。

Objective： To evaluate the relationship between oral contraceptive （OC） usage and the onset risk of hypertension among Chinese women. Methods： Case control study was adopted. 665 female hypertensive cases and 665 female non - hyper-tension controls from Taicang and Rudong district were included in this study. The related factors of hypertension were collected and analyzed using questionnaire and health examination, and all controls were matched according to age and region. Results： The risk of hypertension elevated with the increasing of OC usage time, with a marked dose - response relationship （P = 0.0001 ）. And the risk of hypertension significantly increased among these women with OC usage I〉 15 years （ P = 0. 0196, P =0. 0038） , independent of age and region. Logistic regression analysis showed that： body mass index, family history of hypertension, and the increasing of OC usage time were risk factors of hypertension. And the susceptibility of hypertension a- mong OC users may be different in Taicang and Rudong district. Conclusion： The risk of women hypertension is significantly increased when the OC usage ≥ 15 years. And other potential risk factors of hypertension need to be evaluated in further studies.