皮下埋植避孕妇女血清左炔诺酮含量影响因素分析

Analysis on Influential Factors of Serum Levonorgestrel Levels in Users of Norplant Implants

目的:测定使用Norplant皮下埋植剂妇女血清中左炔诺酮(LNG)水平,分析影响血清LNG水平的因素。方法:应用液相色谱-串联质谱法测定血清中LNG水平。结果:随着使用Norplant时间延长,血清LNG均值缓慢降低;体重<60kg组血清LNG水平高于体重≥60kg组(P<0.05);不规则出血组血清LNG水平明显高于出血规则组(P<0.01)。多因素分析显示,埋植时间、体重和月经类型是影响血清左炔诺酮水平的独立因素。结论:皮下埋植后妇女血清左炔诺酮含量与皮下埋植时间、体重和月经类型密切相关。

Objective： To determine the serum levonorgestrel （LNG） levels in female Users of Norplant implants and analyze the influential factors of serum LNG levels. Methods ： LC - MS/MS methods were adopted to determine the serum LNG levels in 114 women. Results： The average levels of serum LNG gradually decreased with the prolongation of Norplant implants usage. The serum levels of LNG in the group with body weight 〈 60kg were higher than that of body weight ≥60kg （P 〈 0.05 ）, and the serum levels of LNG in the irregular bleeding group were higher than the regular bleeding group （P 〈 0.01 ）. Multi - factor analysis showed that the lasting time of subcutaneous implant, body weight, and menstrual type were the independently influential factors for serum LNG levels. Conclusion ： The serum levels of LNG in users of Norplant implant are closely related to the lasting time of subcutaneous implant, body weight, and menstrual type.