肺肿瘤血管三维重组与CD34标记微血管密度测定相关性研究

Correlative Study of 3D Reconstruction of Lung Tumor Vasculature and CD34 Marked Microvessel Density

目的:研究肺肿瘤血供富乏的多层螺旋CT(MSCT)血管三维重组表现和CD34标记肿瘤微血管密度(MVD),探索方便准确评价肺肿瘤血管供应富乏的新方法,为临床介入治疗提供帮助。方法:采用MSCT血管三维重组计数和瘤体外科手术标本MVD计数两种方法进行血管计数结果对比,分析两者相关性。分析比较肺肿瘤外科手术瘤体标本CD34标记微血管密度值差异。结果:肺恶性肿瘤组织平均MVD值(27.74±3.94)条/高倍目镜(high power lens,HP),明显大于正常组织的MVD值(17.23±6.52)条/HP(P<0.01)。肺肿瘤血供的MSCT三维重组平均(24.72±2.91)条/cm2大于正常肺组织血管MSCT三维重组平均为(13.37±3.21)条/cm2,差异有显著性意义(P<0.05)。结论:MSCT三维重组血管计数与手术瘤体标本CD34微血管密度计数比较,二者有较好的正相关关系,能正确反映瘤体组织供血特点,为临床介入治疗手术选择,准确判定瘤体灌注区域提供新方法。

Objective： The research aims to analyze the three dimensional reconstruction performances of the lung tumor vessel＇s multislice spiral CT （MSCT） and the characteristics of the CD34 marked tumor micro-vessel density （MVD） and to explore new ways of evaluating the vascularity of lung tumor in order to help clinical interventional treatment. Methods： 3D reconstruction performances of lung tumor vaseulature using MSCT and the characterislics of CD34 marked microvessel density （MVD） were analyzed. Their correlation was studied and the difference was compaired. Results： The average micro vessel density of the lung malignant tumor was （27. 74±3. 94）strips/HP,obviously higher than the normal tissue MVD （17.23±6.52） strips/HP （P〈0.01）. The three dimensional reconstruction of lung tumor vessel （24.72±2.91） strips/ cm^2 exceeded that of normal lung vessel （ 13.37±3.21 ） strips/cm^2 , being of statistical significance （P〈0.05 ）. Conclusion ： There is a positive correlation between the three dimensional reconstruction of the lung tumor vessel＇s MSCT and the characteristics of the CD34 marked tumor micro-vessel density （MVD）. This correctly reflects the features of blood-supply of tumor,providing new methods for assessing tumor perfusion area and helping clinical interventional treatment.