硫酸镁干预前后轻度子痫前期孕妇血浆Apelin含量变化的初步研究

Study on the level of Apelin in the plasma of women of mild pre-eclampsia before and after the treatment with magnesium sulfate

目的:研究轻度子痫前期孕妇经硫酸镁干预前后血浆Apelin含量的变化,探讨Apelin与轻度子痫前期的关系。方法:选择轻度子痫前期孕妇21例为观察组,正常孕妇25例为对照组,用放免法测定其血浆Apelin的含量。结果:观察组硫酸镁干预后轻度子痫前期孕妇血浆Apelin含量逐渐升高;硫酸镁干预前与分娩前、硫酸镁干预前与分娩后48 h以及硫酸镁干预后24 h与分娩后48 h血浆Apelin含量比较,差异均有显著性(P<0.05);观察组硫酸镁干预前孕妇血浆Apelin含量较对照组孕妇分娩前含量低,且两者间差异有显著性(P<0.05)。结论:Apelin与子痫前期密切相关,硫酸镁治疗子痫前期可使子痫前期孕妇血浆Apelin水平升高。

Objective： To investigate the level of Apelin in the plasma from the mild pre-eclampsia pregnant women before whom were treated by magnesium sulfate and after that. And to study the relation between Apelin and mild pre-eclampsia. Methods： Use radioimmunoassay to detecte the plasma level of Apelin in the group of 21 cases of mild pre-eclampsia and 25 cases of normal pregnancy. Results ： The level of Apelin in all cases was incresing gradually after the treatment with magnesium sulfate. The content of Apelin in the plasma was significantly increased in the group of mild pre-eclampsia pregnant women before deliveryand 48hours after delivery （P〈0.05）. The content of Apelin in the group of mild pre-eclampsia pregnant was remarkable lower than that in the group of normal pregnancy （P〈0.05）. Conclusion： Apelin is related to mild pre-eclampsia closely. The level of Apelin in the plasma from preeclampsia women was increased after the treatment with magnesium sulfate.