耳穴贴压治疗血管性痴呆疗效对照观察

Controlled study of auricular point taping and pressing therapy for treatment of vascular dementia

目的:评价耳穴贴压治疗血管性痴呆(VD)的疗效。方法:将180例VD患者随机分入耳穴贴压组及西药组,各90例。耳穴贴压组采用耳穴贴压法,选取神门、脑、肾、枕4个耳穴。西药组口服尼莫地平,每次30mg,每天3次。两组均治疗12周,以简易精神状态检查表(MMSE)及日常生活自理能力量表(ADL)为观察指标,并观察其不良反应情况。结果:耳穴贴压组治疗前及治疗12周后MMSE评分分别为18.00±3.88、20.83±3.74,西药组分别为17.80±3.82、20.70±3.53,两组治疗后MMSE评分均有提高(P<0.01),但组间比较差异无统计学意义(P>0.05);耳穴贴压组治疗前及治疗12周后ADL评分分别为44.90±14.84、39.60±12.45,西药组分别为45.70±14.86、39.10±13.44,两组治疗后ADL评分均有下降(P<0.01),组间比较差异无统计学意义(P>0.05)。耳穴贴压组有2例因胶布过敏,出现耳郭严重瘙痒而退出试验;西药组1例出现轻度头晕、1例出现腹泻。结论:耳穴贴压法治疗VD可获得与口服尼莫地平相似的疗效,除个别患者胶布过敏外,无其他不良反应。

Objective To assess the therapeutic effect of auricular point taping and pressing therapy on vascular dementia （VD）. Methods One hundred and eighty cases of vascular dementia were randomly divided into an auricu lar point taping and pressing group and a western medicine group, 90 cases in each group. The auricular point taping and pressing group was treated by auricular point taping and pressing at auricular points Shenmen, Nao （brain）, Shen （kidney）, Zhen （pulvinal）, and the western medicine group by oral administration of Nimodipine, thrice each day, 30 mg each time. They were treated for 12 weeks. The scores of mini-mental state examination （MMSE） and activities of daily living （ADL）, and adverse reaction were observed. Results The scores of MMSE before treatment and 12 weeks after treatment were 18.00±3.88 and 20.83±3.74 in the auricular point taping and pressing group, and 17.80±3.82 and 50.70±3.53 in the western medicine group, respectively, with significant increases in scores of MMSE after treatment in the two groups （both P〈0.01） and with no significant difference between the two groups （P〉0.05）. The scores of ADL before treatment and 12 weeks after treatment were 44.90±14.84 and 39.60±15.45 in the auricular point taping and pressing group, and 45.70±14.86 and 39.10±13.44 in the western medicine group, respectively, with significant decreases after treatment in the two groups （both P〈0.01） and with no significant difference between the two groups （P〉0.05）. In the auricular point taping and pressing group, 2 cases withdrew from the test because adhesive plaster allergic reaction induced severe itch of the auricle. In the western medicine group, one case had mild dizziness and another case had diarrhea respectively. Conclusion Auricular point taping and pressing and Nimodipine have similar therapeutic effect on vascular dementia, and have no obvious adverse reaction, except adhesive plaster allergic reaction.