老年重症药疹33例临床分析

Analysis of 33 Cases of Aged People With Severe Drug Eruption

目的探讨老年重症药疹患者的临床特点。方法对本院2000年1月～2007年12月收治的33例老年重症药疹患者的临床资料进行回顾性分析。结果重症多形红斑型药疹所占比例最高,为48.48%;重症药疹中致敏药物以别嘌呤醇占首位,为32.26%;伴有基础疾病患者的皮疹控制时间及住院天数均较无基础疾病患者长(t值分别为2.377,2.160,P均<0.05),有肝功损害的患者糖皮质激素起始用量大于无肝功能损害的患者(t=2.278,P<0.05)。结论糖皮质激素起始治疗量与重症药疹类型、是否伴有肝脏损害关系密切;皮疹的控制时间及住院天数与是否合并基础疾病有关。

Objective To investigate the clinical features of aged people with severe drug eruption. Methods To analyze the clinical data of 33 aged people with severe drug eruption in our hospital during January 2000 to December 2007. Results SJS accounted for the highest proportion. Opurinol was the commonest initiating drug. The rash - controlled duration and length of hospitalization in inpatients with basis disease were longer than those without it. Dose of initial glucocorticoid in patients who had liver damage was larger than those with no liver damage. Conclusion Does of initial glucocorticoid was correlated both the type of severe drug eruption and liver damage. The rash -controlled duration was correlated with whether there was basis disease.