多个变异系数显著性检验在毒理学研究中的应用

Application of multi-coeffieient of variation significance test for toxicology study

目的建立多个变异系数显著性检验的计算与分析方法。方法采用Bonferroni法确定变异系数显著性检验的水准及各实验组分别与同一对照组比较的变异系数显著性检验计算分析方法。结果确定的变异系数显著性检验水准为α^1=0．0167。与对照组比较，30及60mg／kg染铅组血清中丙氨酸转氨酶活力的均数显著性检验均无统计学意义（P〉0．05），而变异系数显著性检验均有统计学意义（P〈0．0167）；与对照组比较，60mg／kg染铅组血清中天冬酸转氨酶活力均数显著性检验未见统计学意义（P〉0．05），而变异系数显著性检验有统计学意义（P〈0．0167）。结论同时使用均数显著性检验与变异系数显著性检验才能全面反映检测指标的变化情况。

Objective To establish the methods of calculating and analyzing the multi-coefficient of variation significance test for the toxicology study. Methods The paper aimed to confirm the significance level with the method of Bonferroni and then compared the methods of calculating and analyzing of the experiment groups with the control group respectively. Results The significance level of multi-coefficient of variation significance test was confirmed as α^1=0.0167. Compared with the control groups, the activity of ALT in serum both in 30 mg/kg and 60 mg/kg groups did not change in the average significance test, which was not statistically significant （P〉0.05）,while it changed in the variation significance test, which was of statistical significance （P〈0.0167）. The activity of AST in serum in 60 mg/kg group did not change in the average significance test（P〉0.05）,while it changed in the variation significance test （P〈0.0167）. Conclusion The complete changes of the indexes can only be shown by use of both the average significance test and the variation significance test together.