多发性硬化首次发病的特点及误诊分析

The first pathogenetic feature and the analysis of misdiagnosis about the multiple sclerosis

目的探讨多发性硬化（MS）首次发病的特点及误诊原因。方法回顾性分析62例MS首次发病的临床资料。结果MS首次发病以肢体感觉异常、肢体运动及视力障碍等为多发，分别为18例（29．0％）、16例（25．8％）、11例（17．7％），另17例（27．4％）则分别以共济失调、癫痫发作、构音障碍、排尿困难、肢体痛性痉挛、皮肤瘙痒、膝关节疼痛、颈痛、精神异常、眩晕、频繁干呕为首发。误诊24例（38．7％）。结论MS首次发病除常以肢体感觉异常、肢体运动及视力障碍为表现外，还具有多样性、复杂性，误诊率高。

Objective To investigate the first pathogenetic feature and the reason of misdiagnosis about the multiple sclerosis（MS）. Methods To review and analyze 62 eases with the first pathogenetic medical record of MS. Results The most frequent clinical manifestation pf the first pathogenetic MS are the limbs paraesthesia （ 18 cases, 29. 0% ）, dyskinesia （ 16 cases, 25. 8% ） and visual disorder （ 11 cases, 17.7% ）, and the other clinical manifestation are the ataxia, epileptic seizure, dyasarthria, dysuria ,itch of skin, mental anomaly, vertigo and so on. The total of misdiagnosis is 2＇$ eases （38.7%）. Conclusion Except the main clinical manifestation, there are diversity, complexity for first pathogenetie MS,what＇s more the misdiagnosis rate is very high.