米力农的热分析研究(英文)

Thermoanalysis studies on millrinone

目的:研究一种非洋地黄强心苷、非儿茶酚胺类的正性肌力药物米力农(millrinone)的熔点、吸附水、结晶水的含量,确定其结构和晶型变化。方法:用差示扫描量热分析(DSC)和热重分析(TGA)法研究其热变化,利用核磁共振(NMR)实验确定其结构,并结合X-射线衍射实验确定其晶型变化。结果:米力农试样不含结晶水,熔点为314.7℃,试样从201.04℃开始失重,在293.06℃发生微小的晶相转变,从亚稳态晶型转变为稳态晶型;试样发生熔融变化后随即发生完全分解反应,试样最终残留量为23.5%。结论:热分析用于药物晶型研究以及熔点、结晶水含量等的测量具有用量少、快速、灵敏高、检测方便等优点。

Objective ：To characterize the physicochemical properties of cardio cerebrovascular drug milrinone including its contents of absorbed water and water of crystallization, melting phase, and crystallization changes. Methods：Differential scanning calorimetry （DSC） and thermogravimetric analysis （TGA） techniques were conducted to determine the thermal characteristics, nuclear magnetic resonance （NMR）was adopted to determine its structure, and, and X -ray diffraction （XRD） analysis was adopted to determine it＇s crystal type. Results：The sample didn＇t contain any crystallization water, and melted at 314. 7 ℃. Millirinone began to fall apart at 201.04 ℃ with the naphthyridine component decomposed and initiated its crystal transformation at 293.06 ℃ from a metastable phase group to a stable phase. Finally, the sample remained 23.5% by weight. Conclusion： Thermoanalysis has a lot of advantages that study on crystallization, melting point, crystal water, etc, for example, little dosage, high - speed, high -sensitivity and easy detection.