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大鼠梗阻性黄疸对急性胃粘膜病变的影响及洛赛克对它的预防研究 被引量:1

Effect of Obstructive Jaundice on Formation of Gastric Mucosal Lesion in Rats and Prophylastic Effects of Losec
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摘要 通过制作大鼠 O J和 A G M L 模型,研究了 O J对 A G M L 的影响及洛赛克对 A G M L 的预防作用.结果表明: O J能明显加强大鼠应激下 A G M L 的形成,且其 A G M L 的严重性与胆道梗阻时间相关,洛赛克对 O J大鼠应激下 A G M L The effect of obstructive jaundice ( OJ) on the formation of acute gastric mucosal lesion (AGML) in rats and prophylastic effects of Losec were studied by the two models of OJ and AGML. The results of the experiment were as follows: OJ could enhance the formation of AGML in rats under stress, and the severity of AGML was related to duration of biliary tract obstruction, and Losec could inhibit the formation of AGML in OJ rats under stress.
作者 王向昱
出处 《科技通报》 1998年第3期225-228,共4页 Bulletin of Science and Technology
关键词 应激性溃疡 洛赛克 梗阻性黄疸 预防 Rat, Biliary tract, Stress ulcer, Losec
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参考文献2

  • 1Seiichi Mizumoto M.D.,Kazunori Harada M.D., Ph.D.,Sadamu Takano M.D.,Atsunobu Misumi M.D.,Masanobu Akagi M.D.. Mechanisms of acute gastric mucosal lesion accompanying obstructive jaundice[J] 1986,Gastroenterologia Japonica(1):6~16
  • 2Kazunori Harada M.D.,Seiichi Mizumoto M.D.,Atsunobu Misumi M.D.,Atsushi Yamatodani M.D.,Masanobu Akagi M.D.. Studies of the mechanisms of gastric bleeding under obstructive jaundice[J] 1983,Gastroenterologia Japonica(2):71~78

同被引文献6

  • 1Cahill CJ, et al.Prevention of postoperative renal failure in patients with obstructive jaundice:the role of bile salts.Br J Surg,1983,70:590.
  • 2Harada K, et al.Studies of the mechanisms of gastric bleeding under obstructive jaundice:role of biogenic amines.Gastroenterologic Jpn,1983,18:71.
  • 3Itoh M,et al.Role of oxygen derived free fadical in hemorrhagic shock-induced gastric lesions in rat.Gastroenterology,1985,88:1162.
  • 4Peterson WL.The role of acid in upper gastrointestinal haemorrhage due to ulcer and stress-related mucosal damage. Aliment Pharmacol Ther,1995,9(supp11):43-46.
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  • 6Burnner G,Luna P,Thiemann G.Drugs for pH control in upper gastrointestinal bleeding.Aliment Pharmacol Ther,1995,9(suppl):47-50.

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