智子颗粒剂降血铅的临床疗效观察

Clinical Observation on Descending Blood-lead Effects ofFructus Alpiniae Oxyphyllae Particle Form

应用中药智子颗粒剂（方剂组成；枸杞子、益智仁、煅牡蛎、牛磺酸）预防、治疗铅暴露导致儿童亚临床神经毒性。其方法：在一定区域内对年龄7－12岁小学生共399名进行血铅测定，其中血铅值＞20μg／dL（0．965umol／L）16名，随机分成给药组、对照组各60名，开放组42名，用药前后进行血红蛋白、身长、体重、视力测定，并在给药组中给药前后进行血液生化及免疫学检查（ALT、AstBun、Cr、IgG、IgA、IgM），并同时对60例高血铅小儿（30例服药组、30例对照组）服药前后进行心理测试（选用：划消、译码、积木、记忆）综合分析，其结果；用药一个月后给药组与开放组血铅明显下降（P＜O．001），与给药前检查对比降低50％。血红蛋白、免疫球蛋白均有上升（P＜0．001），心理测试几项指标明显高于对照组。结论：智子颗粒剂不仅降血铅，提高免疫功能，改善儿童健康状况，在增强智力方面亦有作用。本剂无肝肾副作用，安全。

This is about prevention and treatment of children's subclinical nenrotrophic toxicity causedby exposure of lead with Chinese traditional medicine Fructus Alpiniae Oxyphyllae particle form (prescription consists of : Lycium chinese, Fructus Alpiniae Oxyphyllae, Concha Ostrea, Taurine). The studywas undertaken by measuring blood - lead of total 399 students at age 712 years old in a certain region,162 of them with blood lead greater than 20 μg/dL (0. 965 μmol/L) were randomly grouped into treatedgroup and control group with 60 people of each, opened group with 42 people. Hemoglobin, stature,weight and vision were measured prior and after taking medicine. In treated group blood biochemical andimmunological indexes (ALT, AST, BUN, Cr, igG, IgA, IgM) were examined prior and after takingmedicine. At the same bine, psychological test was taken is 60 students with higher blood lead (treatedgroup with 30 people and control group with 30 people prior and after taking medicine (select: demarkating, decoding, building blocks, remembering). Through synthesis and analysis, the resultsshowed an obvious descent of blood lead in treated group and opened group (P＜ 0.001 ) after onemonth treatment with this drug compared with prior taking this drug the blood lead is reduced by 50％.Hemoglobin and immunoglobulin are all raised (P＜ 0.001 ). The results of psychological test are obviously higher than control group. Result: Fructus Alpiniae Oxyphyllae particle form not only drops bloodlead, but also rises immune function and improves health and intellectual development of children. Thereisn't side effect on liver and kidney. It's safety.