氨酚羟考酮片对开胸术后镇痛疗效的临床对比研究

A comparative study for analgesic effect of oxycodone-acetaminophen tablet on post-operative pain after thoracotomy

目的:以盐酸曲马多为对照,观察开胸术后氨酚羟考酮的镇痛疗效及安全性。方法:50例开胸术后患者,随机分为氨酚羟考酮组(n=25)和曲马多组(n=25)。分别服用氨酚羟考酮及盐酸曲马多片进行镇痛治疗。应用视觉模拟评分法(Visual analogue scale,VAS)观察治疗前后疼痛强度(PI)变化、疼痛缓解率及不良反应。结果:服氨酚羟考酮的患者首次服药后30min至1hPI下降明显,组内PI值即可出现显著性统计学差异(P<0.05),服药1d后,即能达到满意稳定的镇痛效果,相较于曲马多组,氨酚羟考酮组的PI值在5d的时间基本能维持在较低的水平上,但在统计学上没有显著差异性。服药5d后,两组疼痛缓解有效率均为100%,但疼痛缓解显效率分别为100%和76%,有显著性统计学差异(P<0.05)。各组间不良反应发生率差异无显著性意义。结论:氨酚羟考酮用于开胸术后镇痛安全有效。

Objective： To observe the efficacy and safety of oxyeodone-aeetaminophen tablet （OAT） on post-operative pain in patients with thoraeotomy. Methods： Fifty patients with post-operative pain after thoracotomy were randomly divided into 2 groups （n = 25 for each group）. They were treated with OAT or tramadol for 5 days. The numeric changes in pain intensity（PI） , efficacy rate of relieving pain and the adverse reactions were observed before and after the treatments. Results： In contrast to tramadol group, the PI significantly decreased from 30 rain to 1 h after the first treatment, and the PI value at 1 h was significantly lower than the baseline level in OAT group. From 1 day after the treatment, stability analgesic effect was achieved in the two groups. The total effective rate was 100% in both groups, but the significant rate of pain relief （ 100% ） in OAT group was significantly higher than that （76%） in tramadol group （P 〈 0.05）. There was no significant difference in incidence of adverse reactions between the two groups. Conclusion： Oxycodone-acetaminophen tablet is safe and effective in the treatment of post-operative pain after thoracotomy.