摘要
目的:以盐酸曲马多为对照,观察开胸术后氨酚羟考酮的镇痛疗效及安全性。方法:50例开胸术后患者,随机分为氨酚羟考酮组(n=25)和曲马多组(n=25)。分别服用氨酚羟考酮及盐酸曲马多片进行镇痛治疗。应用视觉模拟评分法(Visual analogue scale,VAS)观察治疗前后疼痛强度(PI)变化、疼痛缓解率及不良反应。结果:服氨酚羟考酮的患者首次服药后30min至1hPI下降明显,组内PI值即可出现显著性统计学差异(P<0.05),服药1d后,即能达到满意稳定的镇痛效果,相较于曲马多组,氨酚羟考酮组的PI值在5d的时间基本能维持在较低的水平上,但在统计学上没有显著差异性。服药5d后,两组疼痛缓解有效率均为100%,但疼痛缓解显效率分别为100%和76%,有显著性统计学差异(P<0.05)。各组间不良反应发生率差异无显著性意义。结论:氨酚羟考酮用于开胸术后镇痛安全有效。
Objective: To observe the efficacy and safety of oxyeodone-aeetaminophen tablet (OAT) on post-operative pain in patients with thoraeotomy. Methods: Fifty patients with post-operative pain after thoracotomy were randomly divided into 2 groups (n = 25 for each group). They were treated with OAT or tramadol for 5 days. The numeric changes in pain intensity(PI) , efficacy rate of relieving pain and the adverse reactions were observed before and after the treatments. Results: In contrast to tramadol group, the PI significantly decreased from 30 rain to 1 h after the first treatment, and the PI value at 1 h was significantly lower than the baseline level in OAT group. From 1 day after the treatment, stability analgesic effect was achieved in the two groups. The total effective rate was 100% in both groups, but the significant rate of pain relief ( 100% ) in OAT group was significantly higher than that (76%) in tramadol group (P 〈 0.05). There was no significant difference in incidence of adverse reactions between the two groups. Conclusion: Oxycodone-acetaminophen tablet is safe and effective in the treatment of post-operative pain after thoracotomy.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2009年第4期334-336,共3页
Chinese Journal of New Drugs
关键词
氨酚羟考酮
术后镇痛
疼痛强度
oxyeodone and acetaminophen tablet
post-operative pain
pain intensity (PI)