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硝苯地平缓释微丸的制备

Preparation of nifedipine sustained-release pellets
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摘要 目的:制备硝苯地平缓释微丸。方法:采用离心造粒法,在离心造粒机内通过制备母核、制备含药微丸、包衣3步完成。结果:释放度符合缓释要求,工艺重现性好。结论:离心造粒法可用于制备硝苯地平缓释微丸。 Objective：To prepare nifedipine sustained-release pellets. Methods： Nifedipine sustained-release pellets were prepared by centrifugal granulation with seed core, loading drug and coating pellets. Results：The pellets met with the release standard and the process was stable. Conclusion：The centrifugal granulation can be used to prepare nifedipine sustained-release pellets.
作者 刘彦生 王宪利 王刚 唐哲
机构地区 武警辽宁省总队医院药剂科
出处 《中国新药杂志》 CAS CSCD 北大核心 2009年第4期356-359,共4页 Chinese Journal of New Drugs
关键词 硝苯地平 缓释微丸 离心造粒法 nifedipine sustained-release pellet centrifugal granulation method
分类号 R943.41 [医药卫生—药剂学] R972.4 [医药卫生—药品]
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参考文献5

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二级参考文献16

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中国新药杂志
2009年 第4期

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