2424例药物不良反应报告分析

Retrospective Analysis on the ADR Reports of 2 424 Cases

目的:分析药品不良反应(ADR)发生的规律及特点,为临床合理用药及药物安全性评价提供依据。方法:对我院2006-2007年收集的2424例ADR报告进行分类统计和分析。结果:药品不良反应涉及17类药物,383个品种,抗感染药居首位(728例,占30.03%),其次是抗肿瘤药(312例,占12.87%)和血液系统药物(224例,占9.24%);静脉用药引发ADR为1848例(占76.24%);严重不良反应205例,以抗感染药(23种)和抗肿瘤药(20种)为主,临床主要表现为高热、寒战、白细胞减少等;ADR可发生于人体各个系统,但主要为消化系统损害(810例),其次为皮肤损害(587例)。结论:临床应重视ADR的报告和监测工作,以减少或避免ADR的发生,促进临床合理用药。

Objective： To study the characteristics and regularities of adverse drug reaction （ADR） occurred in our hospital. Methods： 2 424 ADR cases collected from 2006 to 2007 in our hospital were analyzed statistically. Results： 2 424 ADR cases refered to 17 categories and 383 kinds of drugs. Of which anti-infective agents occupied the first place which had 728 cases （30.03%）. Followed by antineoplastic agents which had 312 cases （12.87%） and blood system agents which had 224 cases （9.24%）. 1 848 cases （76.24%） were given intravenously. 205 cases were severe, of which anti-infective agents occupied the first place （23 kinds）, followed by anti- neoplastic agents （20 kinds）. The clinical manifestations predominantly were hyperpyrexia, shivering, leukoeytopenia and so on. ADRs occurred systemically and were characterized predominantly by alimentary system （810 cases）, followed by skin lesion （587 cases）. Conclusion： Clinic should attach great importance to the monitoring and reporting of ADRs to reduce or avoid the occurrence of ADRs.