MMP-14与TIMP-2在子宫腺肌病中的表达及临床意义

Expression and clinical significance of MMP-14 and TIMP-2 in adenomyoma

目的:探讨MMP-14与TIMP-2在子宫腺肌病异位内膜中的表达及发病机制。方法:采用免疫组织化学方法检测65例子宫腺肌病异位内膜和35例正常子宫内膜中MMP-14与TIMP-2的表达。结果:(1)MMP-14在异位内膜的表达均显著高于正常子宫内膜(P<0.05)。(2)TIMP-2在异位内膜的表达低于正常子宫内膜(P<0.05)。(3)在正常子宫内膜中MMP-14与TIMP-2呈负相关(r=-0.721,P<0.05)。结论:MMP-14与TIMP-2在子宫腺肌病中的表达变化,可能有促进子宫内膜在子宫肌层内的异位种植和生长。

Objective：To detect the expression of MMP-14 and TIMP-2 in eetopic endometrium of adenomyoma and its relation with the pathogenesis of adenomyoma. Methods：Endometrial specimens were obtained from 35 normal uteri and 65 with adenomyoma. MMP-14 and TIMP-2 were detected by immunohistochemical streptavidin-peroxidase staining. Results： （1）Eetopie endometrium expressed higher levels of MMP-14, than eutopic endometrium from normal and EMs patients（P〈0.05）.（2）Eetopic and eutopic endometrium from EMs patients expressed lower levels of TIMP-2 than normal control endometrium. （3）In the normal control endometrinm there was a statistically significant negative correlation between MMP-14 and TIMP-2 expression levels, with correlation coefficients of -0.721 （P〈 0.01）. Conclusion：The expression of MMP-14 and TIMP-2 in ectopic endometria of adenomyoma may cause to change local angiogenesis and enhance the growth and survival of ectopic endometrial implants.