摘要
目的探讨在肺癌诊断过程中支气管肺泡灌洗液(BALF)和血清中肿瘤标志物细胞角蛋白19片段(CYFRA21-1),神经元特异性烯醇化酶(NSE)、癌胚抗原(CEA)含量的变化、敏感程度及联合检测的意义。方法选择确诊的肺癌患者55例作为检测组,肺部良性病变患者55例作为对照组。使用放射免疫(ELISA)方法检测2组患者的BALF和血清中CYFRA21-1、NSE、CEA的含量。结果肺癌患者BALF及血清中肿瘤标物浓度明显高于肺良性病变组(P<0.05),BALF中CYFRA21-1、NSE、CEA均高于血清中含量。结论肺癌患者BALF和血清中CYFRA21-1、NSE、CEA联合检测对肺癌诊断有较高的临床参考价值。
Objective To discuss the significance of CYFRA21-1, NSE, CEA in bronchoalveolar lavage fluid （BALF） in diagnosis, pathology type and stage of lung cancer. Methods Fifty five cases of lung cancer and 55 cases of benign lung disease were enrolled as study group and control group respectively. Enzyme linked immunosorbent assay was used to detect the level of the three tumor markers in serum and BALF in two groups. Results Levels of CYFRA21-1, NSE, CEA in serum and BALF of lung cancr were higher than those in control group, and had significant differences （P 〈 0. 05 ）. Conclusion Detecting levels of CY- FRA21-1, NSE, CEA in lung cancer BALF has significance in diagnosis of lung cancer.
出处
《职业卫生与病伤》
2009年第1期54-56,共3页
Occupational Health and Damage
关键词
肺肿瘤
支气管肺泡灌洗液
肿瘤标记
Lung cancer
Bronchoalveolar lavage fluid
Tumor marker
