C-反应蛋白与尿毒症维持性血液透析患者心血管并发症关系的探讨

The association among C-reactive protein and cardiovascular risk in uremic patients with undergoing maintenance hemodialysis

目的探讨尿毒症维持性血液透析患者C-反应蛋白(C-reactive protein,CRP)与心血管并发症的关系。方法抽取32例尿毒症维持性血液透析患者透析前静脉血,检测血清中CRP、总胆固醇、三酰甘油、高密度脂蛋白胆固醇及低密度脂蛋白胆固醇含量,根据CRP水平分为正常组(CRP≤8mg/L)和升高组(CRP>8mg/L)。结果异常组总胆固醇(CHOL)高于正常组,统计学分析差异具有统计学意义(P<0.05),而三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)差异无统计学意义(P>0.05)。尿毒症维持性血液透析患者血清CRP与CHOL正相关(P<0.05),与TG、HDL-C、LDL-C无相关关系(P>0.05)。结论尿毒症维持性血液透析患者血清CRP是炎症反应较好的预测指标,其对心血管并发症的预防和治疗有一定临床指导意义。

Objective To study association among C-reactive protein and cardiovascular risk in uremic patients with undergoing maintenance hemodialysis. Methods Thirty-two patients on maintenance hemodialysis due to uremia were studied. Blood samples were collected on the same day on hemodialysis at fast and the levels of blood-sermn CRP, total cholestesterol, triglyceride, high-density hpoprotein cholesterol and low-density lipoprotein cholesterol were determined. All patients were divided into normal group （ CRP ≤ 8mg/L） or abnormal group（ CRP 〉 8mg/L）. Results There were significant difference（ P 〈 0.05 ） of serum CHOL between normal CRP patients and abnormal CRP patients. There were no significant difference（ P 〉 0.05） of serum TG, HDL-C and LDL-C between normal CRP patients and abnormal CRP patients. Positive correlation was found between the levels of CRP and CHOL（ P 〈 0.05 ）. Negative correlation was found between the levels of CRP and TG, HDL- C and LDL-C （ P 〉 0.05 ）. Conclusion CRP can be used as better markers of inflammation in patients on maintenance hemodialysis due to uremia which should be beneficial to prevent and treat the various cardiovascular complications of these patients.