食用三邻甲苯磷酸酯污染面粉致瘫痪暴发

Paralysis Outbreak Due to Flour Contaminated with Tri-ortho-cresyl-Phosphate

报道一起因食用三邻甲苯磷酸酯（ＴＯＣＰ）污染面粉所致中毒性周围神经病暴发。总罹患率６０４６５‰，其中红光村罹患率居５个村落之首２６３５６６‰。本病潜伏期长则９４天，短则４０天，平均６４天，流行期有两个发病高峰，患者以儿童和青壮年为主，男女患病比１∶１１２。本病具有明显的家庭聚集性χ２＝１１２３，Ｐ＜００５。经叉生分析，患病危险因素为食用三邻甲苯磷酸酯污染的面粉。经薄层和气象色谱定性及定量分析，自病区面粉等样品中检出ＴＯＣＰ。从流行病学、临床和实验室综合判定了本次瘫痪暴发的病因。

aralysis outbreak due to flour contaminated with Tri-ortho-cresyl phosphate(TOCP) occured in suburban of Xi′an city in 1995.Attack rate was 60465‰.HongGuang village′s was the highest 263566‰ among 5 villages.The attack rate of the second villager group was also higher among 3 villager groups of HongGuang village.Incubation period was 94 days at most,40 days at least and average was 64 days.There were 2 peaks during outbreak.Majority cases was childhood and adults.Gender ratio was 1∶112.The TOCP paralysis had clearly family aggregation χ2=1123,P<005.After high risk factors were analysised on statistics,it was confirmed that high risk factor was flour which was contaminated by TOCP.Also TOCP was checked out from flour and other samples in epidemic zone by useing TCL and Gas Chromatograph.According to epidemiology,clinical medicine and laboratory study,it is confirmed that TOCP was aetiology of the paralysis outbreak.