摘要
目的:观察人参二醇组皂甙对心肌缺血再灌注损伤犬心功能的保护作用。方法:12只杂种犬随机分为人参二醇组皂甙治疗组(PDS)和生理盐水对照组(NS)。结扎冠状动脉左前降支使心肌缺血,90min后恢复血流,复制缺血再灌注损伤模型。分别于缺血即刻静脉滴注PDS(25mg/kg)和100ml生理盐水。结果:PDS组缺血再灌注后LVSP、±dp/dtmax、CO、CI、SI均显著高于NS组,而LVSP和TPVR则明显低于NS组。结论:提示PDS具有保护缺血再灌注损伤心肌心功能的作用。
Objective:Observation on the protective effect of PDS on myocardial cells in ischemia and reperfusion dogs.Methods:Twelve hybrid dogs were rendomly divided into myocardial ischemia reperfusion panaxadiol saponin treated group (PDS) and normal saline control group (NS).Openchest dogs were subjected to left anterior coronary descending artery occlusion for 90 min followed by 4 h reperfusion.Cardiac function were measured before occlusion,90 min after occlusion and 120 min and 240 min after reperfusion.Results:That LVSP,±dp/dtmax,CO and CI in PDS group were obviously higher than those in NS group was shown,but LVEDP and TPVR in PDS group were significantly lower than those in NS group.Conclusion:These results suggest that PDS has protesctive effect on cardiac function of ischemia and reperfusion injury.
出处
《白求恩医科大学学报》
CSCD
1998年第1期16-18,共3页
Journal of Norman Bethune University of Medical Science