7-氰基-3,4-反-环氧庚-1-烯的制备

Synthesis of 7-cyano-3,4-trans-epoxyhep-1-en

简述从四氢吡喃炔丙醇（１）和１－溴－３－氯丙烷（２）开始经七步反应制备７－氰基－３，４－反－环氧庚－１－烯（９）的方法。（９）是合成具有很强抗肿瘤作用的前列腺素Ｊ２的中间体。

7Cyano3,4transepoxyhept1en(9) have been synthesized from tetrahydropyranyl propargyl alcohol and 1bromo3chloropropane in seven steps in this paperThe title compound is a key intermediate in the synthesis of prostaglandin J2 possessing antitumor activity