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胰高血糖素样肽-2分泌与代谢、生物学作用的研究现状 被引量：2

Study actuality on secretion and metabolize of glucagon-like peptide-2
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摘要 胰高血糖素样肽-2(glucagon-like peptide2,GLP-2)是一种多肽类胃肠道激素,具有促进动物肠道生长发育,修复受损伤肠道,加快营养物质转运与吸收,增强肠粘膜屏障功能等生理作用,在畜牧生产上具有广阔的应用前景。 Glucagon-like peptide 2 （GLP-2） is a sort of gastrointestinal polypeptide hormone. GLP-2 displays functions of promoting development of intestine, repairing injured intestine, speeding up nutrients transport and absorption, enhancing intestinal mucosal barrier and so on. Therefore, GLP-2 has broad applying prospect on animal husbandry.
作者 胡家澄 邹晓庭
机构地区 浙江大学饲料科学研究所
出处 《饲料工业》 北大核心 2009年第4期48-50,共3页 Feed Industry
关键词 GLP-2 肠道发育 肠道损伤修复 肠粘膜屏障 GLP-2 intestine development injured intestine repairing intestinal mucosal barrier
分类号 Q48 [生物学—生理学]
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参考文献22

  • 1Yoshikawa H, Miyata I, Eto Y. Serum glucagon-like peptide-2 levels in neonates: Comparison between extremely low-birthweight infants and normal-term infants [J]. Pediatr Int, 2006,48(5):464-469.
  • 2Beyse C, Karpe F, Fielding B A, et al. Interaction between specific fatty acids, GLP-1 and insulin secretion in humans [J]. Diabetologia, 2002, 45(11):1533-1541.
  • 3Recca A S, LaGreca J, Kalitsky J, et al. Monounsaturated fatty acids improve glycemic tolerance through increased secretion of glucagon-like peptide-l[J]. Endocrinology,2001,142(3):1148-1155.
  • 4Hansen L, Hare K J, Hartmann B, et al. Metabolism of glucagonlike peptide-2 in pigs: Role of dipeptidly peptidase Ⅳ[J]. Regul Pept, 2007, 138(2-3): 126-132.
  • 5Le huerou-Luron I, Petersen Y M, Hartmann B, et al. Exogenous GLP-2 has limited effects on weanling-induced intestinal adaptation in piglets [J]. Gastroenterology, 2002, 122(4):A380-A381.
  • 6Meier J J, Nauck M A, Pott A, et al. Glucagon-like peptide 2 stimulates glucagon secretion, enhances lipid absorption, and inhibits gastric acid secretion in humans [J]. Gastroenterology,2006, 30(1):44-54.
  • 7Heer J D, Pedersen J, Orskov C, et al. The alpha cell expresses glucagon-like peptide-2 receptors and glucagon-like peptide-2 stimulates glucagon secretion from the rat pancreas[J]. Diabetologia, 2007, 50(10):2135-2142.
  • 8Petersen Y M, Hartmann B, Holst J J, et al. Introduction of enteral food increases plasma GLP-2 and decreases GLP-2 receptor mRNA abundance during pig development [J]. J Nutr, 2003, 133(6): 1781-1786.
  • 9Pedersen N B, Hjollund K R, Johnsen A H, et al. Porcine glueagon-like peptide-2: Structure, signaling, metabolism and effects[J]. Regnl Pept, 2008, 146(1-3):310-320.
  • 10Orskova C, Hartmanna B, Poulsen S S, et al. GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors [J]. Regul Pept, 2005, 124(1-3):105-112.

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饲料工业
2009年 第4期

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