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西布曲明对肥胖大鼠血清脂肪因子水平的影响

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摘要 目的探讨西布曲明对高脂饮食诱导肥胖大鼠血清脂肪因子水平及胰岛素敏感性的影响。方法以高脂饮食喂养SD大鼠8周建立肥胖模型,给予西布曲明(10mg/kg)干预4周,行高胰岛素正常血糖钳夹试验得到稳态下葡萄糖输注速率,以李氏方法计算胰岛素敏感性,用酶联免疫吸附法检测血清脂肪细胞因子包括抵抗素、脂联素和瘦素水平。结果肥胖大鼠胰岛素敏感性低于正常对照组,血清脂联素及抵抗素低于对照组而瘦素高于对照组。西布曲明干预后肥胖大鼠胰岛素敏感性显著升高,血清瘦素及抵抗素水平有所减低,但差异不显著,而脂联素水平上升显著。结论西布曲明可以提高肥胖大鼠的胰岛素敏感性,其机制可能和其促进脂联素水平升高有关。
作者 于利霞 于婷
出处 《济宁医学院学报》 2009年第1期44-46,共3页 Journal of Jining Medical University
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  • 1Connoley IP, Liu YL, Frost I, et al. Thermogenic effects of sibutramine and its metabolites. Br J Pharmacol, 1999, 126(6) :1487
  • 2Ogihara T, Asano T, Ando K, et al. Insulin resistance with enhanced insulin - signaling in high - salt diet - fed rats. Diabetes, 2001,50 : 573
  • 3李光伟,Step.,L.检测人群胰岛素敏感性的一项新指数[J].中华内科杂志,1993,32(10):656-660. 被引量:2125
  • 4Scheen A J, Ernest P. New antiobesity agents in type 2 diabetes: overview of clinical trials with sibutramine and orlistat. Diabetes Metab,2002,28(6 Pt 1 ) :437
  • 5Kim DM, Yoon SJ, Ahn CW, et al. Sibutramine improves fat distribution and insulin resistance, and increases serum adiponeetin levels in Korean obese nondiabetic premenopausal women. Diabetes Res Clin Pract, 2004, 66 Suppl 1 :S139
  • 6Hung YJ, Chen YC, Pei D, et al. Sibutramine improves insulin sensitivity without alteration of serum adiponectin in obese subjects with Type2 diabetes. Diabet Med, 2005, 22(8):1024
  • 7Yang Q, Graham TE, Mody N, et al. Serum retinal binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature,2005,436:356
  • 8Kadowaki T, Yamauehi T. Adiponectin and adiponectin receptors. Endocr Rev, 2005, 26:439
  • 9Cui H, Cai F, Belsham DD. Anorexigenic hormones leptin, insulin, and alpha - melanocyte - stimulating hormone directly induce neurotensin(NT) gene expression in novel NT- expressing cell models. J Neurosci, 2005, 25:9497
  • 10Steppan CM, Bailey ST, Bhat S, et al. The hormone resistin links obesity to diabetes. Nature,2001,400:307

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