对医院抗生素的使用与细菌耐药性监测的分析

Application of Clinical Antimicrobial Agents and Surveillance of Bacterial Resistance of Hospital

目的监测抗生素的使用与临床主要分离菌的耐药率。方法通过电脑程序调取住院药房抗生素的消耗数量,并按用药频度(DDDs)进行排序;临床分离菌用Kirby Bauer法进行药敏试验。结果头孢菌素类、喹诺酮类、大环内酯类临床用药最为广泛;在抗生素DDDs的排序中前10位包括2种喹诺酮类和6种头孢菌素类,尤其头孢唑啉的使用频率最高。在临床分离菌中最常见的菌种为大肠埃希菌、凝固酶阴性葡萄球菌、铜绿假单胞菌、金黄色葡萄球菌等。结论抗生素管理与临床应用需进一步规范,细菌耐药监测应高度重视。

Objective To monitor the application of clinical antimicrobial agents and the bacterial resistance of 2006 in Shenzhen People＇ s hospital. Methods The DDDs order of antimicrobial agents in 2006 was estimated by computer. Antimicrobial susceptibility of the clinical isolated in 2006 were tested by Kirby-Bauer method. Results In the DDDs order, 2 kinds of 4-quinolones and 6 kinds of cephalosporin ranged in the top 10 seats, cefazolin ranged in the first seat. In clinical separated organisms, Escherichia coli, Coagulase negative staphylococcus （CNS）, Pseudomonas aeruginosa, and Staphylococcus aureus occupied the top 4. Conclusion It is very important to promote the rational use of antibiotics to minimize drug resistance and take effective measures to control the spread of drug resistant bacteria.