泉州市2001—2005年肺结核病人结核分枝杆菌耐药性状况分析

Dynamic analysis of the status of drug resistance of Mycobacterium tuberculosis of pulmonary tuberculosis cases from 2001 to 2005 in Quanzhou

目的评价泉州市结核分枝杆菌的耐药状况。方法连续收集2001—2005年本所门诊及住院肺结核病例的菌株做药敏试验。结果2001—2005年耐药率分别为26.2%、29.1%、27.2%、30.9%和25.6%;初治耐药率分别为14.9%、17.9%、12.8%、9.3%和9.5%;复治耐药率分别为67.6%、69.7%、57.4%、61.9%和68.3%。耐单药率以INH、RFP、SM3药较高。耐多种药率以SH、SR、HR、SHR、HRE、SHRE较高。结论泉州市结核病的耐药率较高,情况较严重,控制耐药的关键是早发现、早治疗,采用DOTS策略彻底治愈传染性肺结核,并做好耐药监测评价工作。

Objective To analyze and evaluate the trend of drugs resistance of Mycobacterium tuberculosis, and to provide evidence for tuberculosis （TB） control. Methods The strains of in-patients and out-patients during the years of 2001--2005 were consecutively collected, and drug susceptibility test （DST） was conducted on the strains. Results The drug resistance rates were 26.2% ,29.1% ,27.2%,30.9% and 25.6% respectively; the rate of initial resistance were 14. 9%, 17.9%, 12.8%, 9.3% and 9.5% respectively; acquired resistance rate were 67. 6%, 69.7%, 57.4%,61.9% and 68. 3%. The single-drug resistant rate to INH, RFP and SM were higher than that to other drugs, The multi-drug resistant rate to SH, SR, HR, SHR, HRE, SHRE combination were higher. Conclusion The total drug resistant rate of TB in Quanzhou is very high and the situation is quite serious, the keys of drug resistance control are early detection and treatment to eompletely cure infectious TB with DOTS strategy, and improve the evaluation of drug resistance monitoring.